中华内科杂志
中華內科雜誌
중화내과잡지
CHINESE JOURNAL OF INTERNAL MEDICINE
2012年
6期
441-444
,共4页
刘升云%郭金燕%张磊%刘章锁%郑朝晖%程根阳%高冠民%张欣%刘桂芝%曾小峰
劉升雲%郭金燕%張磊%劉章鎖%鄭朝暉%程根暘%高冠民%張訢%劉桂芝%曾小峰
류승운%곽금연%장뢰%류장쇄%정조휘%정근양%고관민%장흔%류계지%증소봉
红斑狼疮,系统性%代谢综合征X%糖皮质激素类
紅斑狼瘡,繫統性%代謝綜閤徵X%糖皮質激素類
홍반랑창,계통성%대사종합정X%당피질격소류
Lupus erythematosus,systemic%Metabolic syndrome X%Glucocorticoids
目的 初步探讨系统性红斑狼疮(SLE)患者代谢综合征(MS)的发生及其与糖皮质激素应用的关系.方法 选SLE患者116例(SLE组)和健康体检人群115例(对照组),分析2组受试者的MS发生情况.根据有无合并MS,将患者分为SLE合并MS组与SLE未合并MS组,分析2组患者的疾病特点、累计及目前糖皮质激素、羟氯喹的使用情况.结果 SLE组MS的发生率(34.48％)明显高于对照组(14.78％),HDL-C降低、高甘油三酯血症及高血压的患者比例(50.86％,56.03％,46.55％)均高于对照组(34.78％,16.52％,20.00％).SLE合并MS组患者腹围、BMI、收缩压、舒张压高于SLE未合并MS组,HDL-C水平低于SLE未合并MS组,差异有统计学意义(p值均＜0.05)；SLE合并MS组与SLE未合并MS组间病程、肾脏受累比例、ESR、C反应蛋白、超敏C反应蛋白、SLE疾病活动指数、累计及目前糖皮质激素使用量差异均无统计学意义(P值均＞0.05),SLE未合并MS组使用羟氯喹的患者比例(46.05％)高于SLE合并MS组(15.00％).结论 SLE患者MS的发生率高,使用羟氯喹治疗可能减少SLE患者MS的发生.
目的 初步探討繫統性紅斑狼瘡(SLE)患者代謝綜閤徵(MS)的髮生及其與糖皮質激素應用的關繫.方法 選SLE患者116例(SLE組)和健康體檢人群115例(對照組),分析2組受試者的MS髮生情況.根據有無閤併MS,將患者分為SLE閤併MS組與SLE未閤併MS組,分析2組患者的疾病特點、纍計及目前糖皮質激素、羥氯喹的使用情況.結果 SLE組MS的髮生率(34.48％)明顯高于對照組(14.78％),HDL-C降低、高甘油三酯血癥及高血壓的患者比例(50.86％,56.03％,46.55％)均高于對照組(34.78％,16.52％,20.00％).SLE閤併MS組患者腹圍、BMI、收縮壓、舒張壓高于SLE未閤併MS組,HDL-C水平低于SLE未閤併MS組,差異有統計學意義(p值均＜0.05)；SLE閤併MS組與SLE未閤併MS組間病程、腎髒受纍比例、ESR、C反應蛋白、超敏C反應蛋白、SLE疾病活動指數、纍計及目前糖皮質激素使用量差異均無統計學意義(P值均＞0.05),SLE未閤併MS組使用羥氯喹的患者比例(46.05％)高于SLE閤併MS組(15.00％).結論 SLE患者MS的髮生率高,使用羥氯喹治療可能減少SLE患者MS的髮生.
목적 초보탐토계통성홍반랑창(SLE)환자대사종합정(MS)적발생급기여당피질격소응용적관계.방법 선SLE환자116례(SLE조)화건강체검인군115례(대조조),분석2조수시자적MS발생정황.근거유무합병MS,장환자분위SLE합병MS조여SLE미합병MS조,분석2조환자적질병특점、루계급목전당피질격소、간록규적사용정황.결과 SLE조MS적발생솔(34.48％)명현고우대조조(14.78％),HDL-C강저、고감유삼지혈증급고혈압적환자비례(50.86％,56.03％,46.55％)균고우대조조(34.78％,16.52％,20.00％).SLE합병MS조환자복위、BMI、수축압、서장압고우SLE미합병MS조,HDL-C수평저우SLE미합병MS조,차이유통계학의의(p치균＜0.05)；SLE합병MS조여SLE미합병MS조간병정、신장수루비례、ESR、C반응단백、초민C반응단백、SLE질병활동지수、루계급목전당피질격소사용량차이균무통계학의의(P치균＞0.05),SLE미합병MS조사용간록규적환자비례(46.05％)고우SLE합병MS조(15.00％).결론 SLE환자MS적발생솔고,사용간록규치료가능감소SLE환자MS적발생.
Objective To investigate the incidence and correlative factors of metabolic syndrome (MS) in patients with systemic lupus erythematosus (SLE).Methods A total of 116 SLE patients and 115 controls were enrolled into the study.The incidence of MS,SLE disease activity index(SLEDAI) of patients with SLE combined with MS (MS-SLE) and patients without MS (n-MS-SLE),lupus characteristics,cumulative glucocorticoids,administration dose of glucocorticoids and hydroxychloroquine were compared between SLE group and the control group.Results The incidence of MS of SLE group was obviously higher than that of the control ( 34.48％ vs 14.78％,P ＜ 0.05 ).The ratios of patients with lower HDL-C,higher TG and higher blood pressure in SLE group ( 50.86％,56.03％,46.55％ ) were higher than those in the controls ( 34.78％,16.52％,20.00％,all P ＜ 0.05 ).MS-SLE group had significantly higher mean waist circumference,BMI,systolic blood pressure and diastolic blood pressure and lower HDL-C than n-MS-SLE group (all P ＜0.05 ).No significant difference was found regarding duration of disease,renal involvement,ESR,C-reactive protein,high-sensitivity C-reactive protein,SLEDAI,cumulative and current glucocorticoids use in MS-SLE group and n-MS-SLE group.The ratio of patients taking hydroxychloroquine in n-MS-SLE group was higher than that of MS-SLE group (46.05％ vs 15.00％,P＜0.05).Conclusions Patients with SLE has a higher incidence rate of MS.Hydroxychloroquine may reduce their MS incidence.
