CAJ | 학술논문

目的：比较肝动脉化疗栓塞（ TACE）联合射频消融（ RFA）治疗肝细胞癌与单纯TACE治疗的临床疗效。方法搜集自2007年1月至2011年1月208例肝细胞癌介入治疗的患者并进行分组，纳入研究范围标准为肝功能child分级A～B级，最大肿块直径（或2～3个病变直径总和）3.0～10.0cm，其中行TACE＋RFA患者为治疗组共98例，对照组TACE患者110例。分别从临床症状、影像学表现、甲胎蛋白（ AFP）数值、复发率、生存期等方面进行比较分析，评价临床疗效。结果治疗组与对照组在肿瘤坏死程度、肿瘤复发比率、AFP数值变化、生存期方面比较，差异有统计学意义（ P＜0.05）。结论肝动脉化疗栓塞术联合射频消融术治疗肝细胞癌，临床治疗效果优于单纯肝动脉化疗栓塞术，是治疗肝细胞癌非手术患者的有效方法。
목적：비교간동맥화료전새（ TACE）연합사빈소융（ RFA）치료간세포암여단순TACE치료적림상료효。방법수집자2007년1월지2011년1월208례간세포암개입치료적환자병진행분조，납입연구범위표준위간공능child분급A～B급，최대종괴직경（혹2～3개병변직경총화）3.0～10.0cm，기중행TACE＋RFA환자위치료조공98례，대조조TACE환자110례。분별종림상증상、영상학표현、갑태단백（ AFP）수치、복발솔、생존기등방면진행비교분석，평개림상료효。결과치료조여대조조재종류배사정도、종류복발비솔、AFP수치변화、생존기방면비교，차이유통계학의의（ P＜0.05）。결론간동맥화료전새술연합사빈소융술치료간세포암，림상치료효과우우단순간동맥화료전새술，시치료간세포암비수술환자적유효방법。
Objective To compare the clinical efficacy of treatment hepatocellular carcinoma with transcatheter arterial chemo -embolization (TACE) combined radiofrequency ablation (RFA) and TACE alone.Methods collected hospitalized patients from January 2007 to January 2011,208 cases of hepatocellular carcinoma in patients with interventional treatment group ,included in the study criteria for the classification of liver function child A ~B grade,maximum tumor diameter ( or 2~3 lesions diameter sum ) 3.0~10.0cm,where the line for the treatment of patients with TACE +RFA group of 98 patients in the control group TACE 110 patients.Respectively,from the comparative analysis of the clinical symptoms ,imaging findings,alpha-fetoprotein (AFP) values,the recurrence rate,survival,etc.,to evaluate the clinical efficacy.Results The difference was statistically significant between the treat-ment group and the control group in tumor necrosis ,tumor recurrence rate ,AFP value change ,survival aspects ( P<0.05 ) .Conclu-sion The hepatocellular carcinoma clinical outcomes of Hepatic arterial chemoembolization combined with radiofrequency ablation is better than the hepatic artery chemoembolization.This is an effective non-surgical method for the treatment of patients with hepatocel-lular carcinoma .