广州化工
廣州化工
엄주화공
GUANGZHOU CHEMICAL INDUSTRY AND TECHNOLOGY
2011年
14期
87-88,151
,共3页
噻吩%氢溴酸%2-噻吩乙醇%溴化%格式反应%工艺改进
噻吩%氫溴痠%2-噻吩乙醇%溴化%格式反應%工藝改進
새분%경추산%2-새분을순%추화%격식반응%공예개진
thiophene%hydrobromide%2 - thiophene ethanol%bromination%grignard process%process improvement
以噻吩为起始物料，氢溴酸经氧化剂氧化、溴化、格式反应制得格式试剂，格式试剂与环氧乙烷反应，水解得到2－噻吩乙醇，总收率可达72％以上。与溴素溴化相比该改进更适合工业化生产，环境更友好。
以噻吩為起始物料，氫溴痠經氧化劑氧化、溴化、格式反應製得格式試劑，格式試劑與環氧乙烷反應，水解得到2－噻吩乙醇，總收率可達72％以上。與溴素溴化相比該改進更適閤工業化生產，環境更友好。
이새분위기시물료，경추산경양화제양화、추화、격식반응제득격식시제，격식시제여배양을완반응，수해득도2－새분을순，총수솔가체72％이상。여추소추화상비해개진경괄합공업화생산，배경경우호。
The method for synthesis of 2 -thiophene ethanol was got that using thiophene as starting material, hydro.bromic acid oxidized by oxidants, bromination, reacted with magnesium to obtain grignard reagents, then reacted with ethylene oxide, and hydrolyzed to obtain 2 - thiophene ethanol. The total yield can be more than 72%. Comparing with direct bromination with bromine, the method was more suitable for commercial production and environmentally friendly.
