中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2008年
9期
903-905
,共3页
邬伟明%黄勤欢%彭慧玉%黄小玲%高少芬%张妍%李月婵%郑晓滨%黄瑾
鄔偉明%黃勤歡%彭慧玉%黃小玲%高少芬%張妍%李月嬋%鄭曉濱%黃瑾
오위명%황근환%팽혜옥%황소령%고소분%장연%리월선%정효빈%황근
慢性肺源性心脏病%PAC-1%CD62p%流式细胞术
慢性肺源性心髒病%PAC-1%CD62p%流式細胞術
만성폐원성심장병%PAC-1%CD62p%류식세포술
Chronic cot pulmonale%PAC-1%CD62p%Flow cytometry
目的 探讨慢性肺源性心脏病患者血小板活化状态的变化及其临床意义. 方法 用三色全血流式细胞术测定40例慢性肺源性心脏病患者和30例健康对照者外周血中血小板PAC-1、CD62p的表达水平.多普勒超声心动图检测肺动脉收缩压,行动脉血气检测分析. 结果 慢性肺源性心脏病组PAC-1、CD62p的表达均明显高于正常对照组(P<0.01). 结论 慢性肺源性心脏病患者血小板明显活化,其活化程度与肺动脉高压、缺氧和二氧化碳潴留关系密切.
目的 探討慢性肺源性心髒病患者血小闆活化狀態的變化及其臨床意義. 方法 用三色全血流式細胞術測定40例慢性肺源性心髒病患者和30例健康對照者外週血中血小闆PAC-1、CD62p的錶達水平.多普勒超聲心動圖檢測肺動脈收縮壓,行動脈血氣檢測分析. 結果 慢性肺源性心髒病組PAC-1、CD62p的錶達均明顯高于正常對照組(P<0.01). 結論 慢性肺源性心髒病患者血小闆明顯活化,其活化程度與肺動脈高壓、缺氧和二氧化碳潴留關繫密切.
목적 탐토만성폐원성심장병환자혈소판활화상태적변화급기림상의의. 방법 용삼색전혈류식세포술측정40례만성폐원성심장병환자화30례건강대조자외주혈중혈소판PAC-1、CD62p적표체수평.다보륵초성심동도검측폐동맥수축압,행동맥혈기검측분석. 결과 만성폐원성심장병조PAC-1、CD62p적표체균명현고우정상대조조(P<0.01). 결론 만성폐원성심장병환자혈소판명현활화,기활화정도여폐동맥고압、결양화이양화탄저류관계밀절.
Objective To investigate the clinical significance of piatelet activity in patients with chronic cor Dulmonale.Methods PAC-1 and CD62p was measured with flow cytometry in whole blood samples from 40 patients and 30 normal controls.The pulmonary arterial pressure was detected through Doppler echocardiography.The arterial partial pressure of oxygen and the carbon dioxide were also analyzed.Results PAC-1 and CD62p increased significantiy (P<0.01).Conclusion Platelet activity is positively related to pulmonary artrial systolic pressure,CO2 partial pressure,and negatively related to O2 partial pressure.
