CAJ | 학술논문

胰岛移植是一种治疗糖尿病的有效方法,却因供体来源缺乏和免疫排斥等问题难以广泛应用.在正常机体中,胰岛β细胞的再生与凋亡处于动态平衡中.胰腺损伤等条件能刺激内源性B细胞再生以满足机体对胰岛素的需求.成体中内源性β细胞再生的来源主要包括胰腺干/祖细胞分化、β细胞自身分裂增殖和其他类型细胞转分化3种途径.一些小分子药物及非β细胞的移植能够有效刺激内源性β细胞的再生,有望成为治疗糖尿病的新方法.
이도이식시일충치료당뇨병적유효방법,각인공체래원결핍화면역배척등문제난이엄범응용.재정상궤체중,이도β세포적재생여조망처우동태평형중.이선손상등조건능자격내원성B세포재생이만족궤체대이도소적수구.성체중내원성β세포재생적래원주요포괄이선간/조세포분화、β세포자신분렬증식화기타류형세포전분화3충도경.일사소분자약물급비β세포적이식능구유효자격내원성β세포적재생,유망성위치료당뇨병적신방법.
Transplantation of islets offers an attractive strategy for the treatment of diabetes, but its wide application has been limited by donor shortage and immunological rejection after transplantation. During normal pancreatic tissue turnover, the renewal and apoptosis of β cells are in homeostasis. After the destruc-tion of existing β cells through physical or chemical injuries, β cells could be regenerated from pancreatic