国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2012年
1期
77-80
,共4页
血小板微粒%急性冠脉综合征%IL-6
血小闆微粒%急性冠脈綜閤徵%IL-6
혈소판미립%급성관맥종합정%IL-6
Platelet microparficles%Acute coronary syndrome%Interleukin-6
目的 研究急性冠脉综合征(ACS)患者血小板微粒(PMP)的数量变化及其与IL-6的相关性.方法 选取26例ACS,包括12例心肌梗塞(MI)和14例不稳定性心绞痛(UA)患者,12例稳定性心绞痛(SA)和12例健康人作为研究对象.采用流式细胞术对血浆中的PMP数量进行检测,同时采用酶联免疫吸附法(ELISA)测定血清IL-6水平.结果 4组患者PMP数量比较差异有统计学意义(F=28.05,P＜0.001).MI组[(6.82 ±2.12)×105/ml]或UA组[(6.09 ±1.44)×105/ml]的PMP数量分别与SA组[(2.34±1.33)×105/ml]比较均显著增高(均P＜0.001)；MI组或UA组的PMP数量分别与正常对照组[ (2.27±1.40)×105/ml]比较均显著增高(均P＜0.001).PMP与IL-6比较差异有统计学意义(r=0.567,P＜0.001).结论 PMP可能有助于ACS患者血栓的形成和增强炎症性反应.
目的 研究急性冠脈綜閤徵(ACS)患者血小闆微粒(PMP)的數量變化及其與IL-6的相關性.方法 選取26例ACS,包括12例心肌梗塞(MI)和14例不穩定性心絞痛(UA)患者,12例穩定性心絞痛(SA)和12例健康人作為研究對象.採用流式細胞術對血漿中的PMP數量進行檢測,同時採用酶聯免疫吸附法(ELISA)測定血清IL-6水平.結果 4組患者PMP數量比較差異有統計學意義(F=28.05,P＜0.001).MI組[(6.82 ±2.12)×105/ml]或UA組[(6.09 ±1.44)×105/ml]的PMP數量分彆與SA組[(2.34±1.33)×105/ml]比較均顯著增高(均P＜0.001)；MI組或UA組的PMP數量分彆與正常對照組[ (2.27±1.40)×105/ml]比較均顯著增高(均P＜0.001).PMP與IL-6比較差異有統計學意義(r=0.567,P＜0.001).結論 PMP可能有助于ACS患者血栓的形成和增彊炎癥性反應.
목적 연구급성관맥종합정(ACS)환자혈소판미립(PMP)적수량변화급기여IL-6적상관성.방법 선취26례ACS,포괄12례심기경새(MI)화14례불은정성심교통(UA)환자,12례은정성심교통(SA)화12례건강인작위연구대상.채용류식세포술대혈장중적PMP수량진행검측,동시채용매련면역흡부법(ELISA)측정혈청IL-6수평.결과 4조환자PMP수량비교차이유통계학의의(F=28.05,P＜0.001).MI조[(6.82 ±2.12)×105/ml]혹UA조[(6.09 ±1.44)×105/ml]적PMP수량분별여SA조[(2.34±1.33)×105/ml]비교균현저증고(균P＜0.001)；MI조혹UA조적PMP수량분별여정상대조조[ (2.27±1.40)×105/ml]비교균현저증고(균P＜0.001).PMP여IL-6비교차이유통계학의의(r=0.567,P＜0.001).결론 PMP가능유조우ACS환자혈전적형성화증강염증성반응.
Objective To investigate alterations in the amount of platelet microparticles (PMPs) in patients with acute coronary syndrome (ACS),and to evaluate the possible relationship between PMPs and interleukin-6 (IL-6).Method We studied 26 patients with ACS,including 12 patients with myocardial infarction (MI) and 14 patients with unstable angina (UA),12 patients with stable angina (SA) and 12 healthy subjects.The amount of PMPs in the plasma was measured by flow cytometry.The levels of IL-6 in the blood were determined by ELISA.Results Compared between groups,the amount of PMPs was significantly different (F=28.05,P ＜0.001 ).Compared with patients with SA [ (2.34 ± 1.33) × 105/ml],the amount of PMPs was significantly elevated in patients with MI [ (6.82 ± 2.12) × 105/ml] or UA [ (6.09 ± 1.44) ×105/ml] (P ＜ 0.001 ),respectively.The amount of PMPs was significantly elevated in patients with MI or UA compared with healthy subjects [ (2.27 ± 1.40) × 105/ml] (P ＜ 0.001 ),respectively.The level of PMPs was significantly correlated with the level of IL-6 ( r =0.567,P ＜ 0.001 ).Conclusion These results suggest that PMPs may contribute to the development of thrombus and enhance the inflammation in patients with ACS.
