中华糖尿病杂志
中華糖尿病雜誌
중화당뇨병잡지
CHINES JOURNAL OF DLABETES MELLITUS
2012年
1期
13-17
,共5页
詹勇%韩学尧%郭乌兰%吕超%孙秀芹%张晓梅%罗樱樱%张秀英%任倩%周翔海%纪立农
詹勇%韓學堯%郭烏蘭%呂超%孫秀芹%張曉梅%囉櫻櫻%張秀英%任倩%週翔海%紀立農
첨용%한학요%곽오란%려초%손수근%장효매%라앵앵%장수영%임천%주상해%기립농
糖尿病,2型%基因%肥胖%黑素皮质素受体4%含钾通道四聚化结构域15基因
糖尿病,2型%基因%肥胖%黑素皮質素受體4%含鉀通道四聚化結構域15基因
당뇨병,2형%기인%비반%흑소피질소수체4%함갑통도사취화결구역15기인
Diabetes mellitus,type 2%Gene%Obesity%Melanocortin 4 receptor%Potassium channel tetramerisation domain containing 15
目的 评价中国汉族人群黑素皮质素受体4(MC4R)基因和含钾通道四聚化结构域15(KCTD15)基因单核苷酸多态性(SNP)位点rs17782313和rs11084753与2型糖尿病、肥胖及其相关性状的关系.方法 研究对象来自北京居住的社区人群和北京大学人民医院门诊患者,2型糖尿病患者1177例(男性504例,女性673例),非糖尿病正常对照1113名(男316名,女797名).从正常对照人群中选择体质指数(BMI) ≥28.0 kg/m2归为肥胖组(210名),BMI为18.5 ～ 23.9 kg/m2者归为体重正常组(389名).采用飞行时间质谱分析法对rs17782313及rs11084753进行基因分型.各组间率的比较采用卡方检验.结果 调整年龄、性别和BMI后,在隐性、显性及相加遗传模式下,MC4R-rs17782313和KCTD-rs11084753与2型糖尿病均无相关性(均P＞0.05).调整性别和年龄后,rs17782313在显性遗传模式下基因型与肥胖的发病相关,OR值为1.43(95％ CI 1.01 ～2.02),P=0.042,而在相加模式和隐性模式下均未发现基因型与肥胖相关.rs11084753在三种遗传模式下与肥胖的发病均无相关性(均P ＞0.05).正常糖耐量人群中,rs17782313和rs11084753三种基因型间年龄、BMI、腰臀比、空腹血糖、口服糖耐量试验2h血糖和空腹胰岛素差异均无统计学意义(均P＞0.05).结论 中国汉族人群中,MC4R基因SNP位点rs17782313和KCTD15基因SNP位点rs11084753与2型糖尿病无相关性,MC4R基因SNP位点rs17782313可能与中国汉族人群肥胖相关.
目的 評價中國漢族人群黑素皮質素受體4(MC4R)基因和含鉀通道四聚化結構域15(KCTD15)基因單覈苷痠多態性(SNP)位點rs17782313和rs11084753與2型糖尿病、肥胖及其相關性狀的關繫.方法 研究對象來自北京居住的社區人群和北京大學人民醫院門診患者,2型糖尿病患者1177例(男性504例,女性673例),非糖尿病正常對照1113名(男316名,女797名).從正常對照人群中選擇體質指數(BMI) ≥28.0 kg/m2歸為肥胖組(210名),BMI為18.5 ～ 23.9 kg/m2者歸為體重正常組(389名).採用飛行時間質譜分析法對rs17782313及rs11084753進行基因分型.各組間率的比較採用卡方檢驗.結果 調整年齡、性彆和BMI後,在隱性、顯性及相加遺傳模式下,MC4R-rs17782313和KCTD-rs11084753與2型糖尿病均無相關性(均P＞0.05).調整性彆和年齡後,rs17782313在顯性遺傳模式下基因型與肥胖的髮病相關,OR值為1.43(95％ CI 1.01 ～2.02),P=0.042,而在相加模式和隱性模式下均未髮現基因型與肥胖相關.rs11084753在三種遺傳模式下與肥胖的髮病均無相關性(均P ＞0.05).正常糖耐量人群中,rs17782313和rs11084753三種基因型間年齡、BMI、腰臀比、空腹血糖、口服糖耐量試驗2h血糖和空腹胰島素差異均無統計學意義(均P＞0.05).結論 中國漢族人群中,MC4R基因SNP位點rs17782313和KCTD15基因SNP位點rs11084753與2型糖尿病無相關性,MC4R基因SNP位點rs17782313可能與中國漢族人群肥胖相關.
목적 평개중국한족인군흑소피질소수체4(MC4R)기인화함갑통도사취화결구역15(KCTD15)기인단핵감산다태성(SNP)위점rs17782313화rs11084753여2형당뇨병、비반급기상관성상적관계.방법 연구대상래자북경거주적사구인군화북경대학인민의원문진환자,2형당뇨병환자1177례(남성504례,녀성673례),비당뇨병정상대조1113명(남316명,녀797명).종정상대조인군중선택체질지수(BMI) ≥28.0 kg/m2귀위비반조(210명),BMI위18.5 ～ 23.9 kg/m2자귀위체중정상조(389명).채용비행시간질보분석법대rs17782313급rs11084753진행기인분형.각조간솔적비교채용잡방검험.결과 조정년령、성별화BMI후,재은성、현성급상가유전모식하,MC4R-rs17782313화KCTD-rs11084753여2형당뇨병균무상관성(균P＞0.05).조정성별화년령후,rs17782313재현성유전모식하기인형여비반적발병상관,OR치위1.43(95％ CI 1.01 ～2.02),P=0.042,이재상가모식화은성모식하균미발현기인형여비반상관.rs11084753재삼충유전모식하여비반적발병균무상관성(균P ＞0.05).정상당내량인군중,rs17782313화rs11084753삼충기인형간년령、BMI、요둔비、공복혈당、구복당내량시험2h혈당화공복이도소차이균무통계학의의(균P＞0.05).결론 중국한족인군중,MC4R기인SNP위점rs17782313화KCTD15기인SNP위점rs11084753여2형당뇨병무상관성,MC4R기인SNP위점rs17782313가능여중국한족인군비반상관.
Objective To investigate the associations of two obesity susceptibility genetic variants:melanocortin 4 receptor(MC4R) and potassium channel tetramerisation domain containing 15 (KCTD15)single nucleotide polymorphisms rs17782313 and rs11084753 with type 2 diabetes mellitus (T2DM) and T2DM-related traits in Chinese Han population.Methods A total of 1177 type 2 diabetic (male 504 and female 673) and 1113 subjects with normal glucose tolerances (male 316 and female 797) were recruited from Beijing communities and outpatients of Peking University People's Hospital.The participants with a BMI ≥28.0 kg/m2 as obesity group and those with a BMI of 18.5-23.9 kg/m2 as normal weight group from normal glucose tolerance subjects were chosen for study.MC4R-rs17782313 and KCTD15-rs11084753 were genotyped by using MassARRAY iPLEX system.The rates among the groups were compared by x2 test.Results After adjusting age,sex and body mass index (BMI),no associations between rs17782313 and rs11084753 with T2DM was found under additive,dominant or recessive models (P ＞ 0.05 ).Under the dominant model,it's confirmed that rs17782313 was associated with obesity after adjusted for age and sex,with a odds ratio of 1.43 (95％ CI 1.01-2.02),P =0.042,but no association was found under additive and recessive models.No association was found between rs11084753 and obesity under the up-mentioned three genetic models.In addition,analysis of clinical features in normal glucose tolerance subjects showed no differences in age,BMI,waist to hip ratio,fasting plasma glucose,OGTT 2-hour glucose and fasting serum insulin among three genotypes of rs17782313 and rs11084753 ( all P ＞ 0.05),respectively.Conclusion In Chinese Han population,MC4R-rs17782313 and KCTD15-rs11084753 are not associated with type 2 diabetes,although a borderline association signal between MC4R-rs17782313 and obesity is detected.
