肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2011年
7期
502-504
,共3页
雌激素受体α%雌激素受体β%乳腺肿瘤
雌激素受體α%雌激素受體β%乳腺腫瘤
자격소수체α%자격소수체β%유선종류
Estrogen receptor alpha%Estrogen receptor beta%Breast neoplasms
乳腺癌是一种激素依赖性肿瘤.雌激素受体α(ERα)在雌激素介导的乳腺癌发生、发展中起重要作用.然而,最近研究发现乳腺癌细胞的雌激素受体存在另一亚型——雌激素受体β(ERβ),也可能在乳腺癌的发生、发展中起重要作用.与ERα的作用不同,ERβ在细胞实验和动物模型研究中表现出对乳腺癌细胞增殖抑制作用.文章从ERβ与ERα及孕激素受体(PR)的关系、乳腺癌浸润与转移及对内分泌治疗的影响等方而阐述其与乳腺癌的关系.
乳腺癌是一種激素依賴性腫瘤.雌激素受體α(ERα)在雌激素介導的乳腺癌髮生、髮展中起重要作用.然而,最近研究髮現乳腺癌細胞的雌激素受體存在另一亞型——雌激素受體β(ERβ),也可能在乳腺癌的髮生、髮展中起重要作用.與ERα的作用不同,ERβ在細胞實驗和動物模型研究中錶現齣對乳腺癌細胞增殖抑製作用.文章從ERβ與ERα及孕激素受體(PR)的關繫、乳腺癌浸潤與轉移及對內分泌治療的影響等方而闡述其與乳腺癌的關繫.
유선암시일충격소의뢰성종류.자격소수체α(ERα)재자격소개도적유선암발생、발전중기중요작용.연이,최근연구발현유선암세포적자격소수체존재령일아형——자격소수체β(ERβ),야가능재유선암적발생、발전중기중요작용.여ERα적작용불동,ERβ재세포실험화동물모형연구중표현출대유선암세포증식억제작용.문장종ERβ여ERα급잉격소수체(PR)적관계、유선암침윤여전이급대내분비치료적영향등방이천술기여유선암적관계.
Breast cancer is a hormone-dependent malignant carcinoma. Many well-established studies have shown estrogen receptor , especially estrogen receptor alpha (ERα), play an important role in the development of breast cancer. Recently, increasing evidences have shown that another subtype of estrogen receptor,estrogen receptor beta (ER β), may play an important role in the development of breast cancer. In contrast to the function of ERa, ER β played an anti-proliferation role in cell model and animal experiments of breast cancer. We review the recent articles on the relationship between ERB and invasion and metastasis of breast cancer, the coexpression and interaction among ERβ , ERα and PR.
