国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
INTERNATIONAL JOURNAL OF ANESTHESIOLOGY AND RESUSCITATION
2012年
4期
284-288
,共5页
于熔%刘成晓%徐军美%戴茹萍
于鎔%劉成曉%徐軍美%戴茹萍
우용%류성효%서군미%대여평
脑源性神经营养因子%心肌重塑%基因多态性%血管新生%心肌细胞凋亡%炎症反应
腦源性神經營養因子%心肌重塑%基因多態性%血管新生%心肌細胞凋亡%炎癥反應
뇌원성신경영양인자%심기중소%기인다태성%혈관신생%심기세포조망%염증반응
Brain -derived neurotrophic factor%Myocardial remodeling%Genetic polymorphism%Angiogenesis%Apoptotic cardiomyocytes%Inflammatory response
背景 脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)是神经营养因子家族最具代表性的成员之一.最近研究表明BDNF亦在心血管系统表达,且与急性心肌梗死(acute myocardial infarction,AMI)后心肌重塑密切相关.目的 分析总结BDNF与AMI后心肌重塑相关性的文献资料.内容 从基因多态性、血管新生、心肌细胞凋亡、炎症反应,就BDNF与AMI后心肌重塑相关性加以描述. 趋向 AMI后心肌重塑BDNF在心肌表达明显上调.BDNF以其独特的生物学功能,有望为心肌重塑开辟新的治疗途径.
揹景 腦源性神經營養因子(brain-derived neurotrophic factor,BDNF)是神經營養因子傢族最具代錶性的成員之一.最近研究錶明BDNF亦在心血管繫統錶達,且與急性心肌梗死(acute myocardial infarction,AMI)後心肌重塑密切相關.目的 分析總結BDNF與AMI後心肌重塑相關性的文獻資料.內容 從基因多態性、血管新生、心肌細胞凋亡、炎癥反應,就BDNF與AMI後心肌重塑相關性加以描述. 趨嚮 AMI後心肌重塑BDNF在心肌錶達明顯上調.BDNF以其獨特的生物學功能,有望為心肌重塑開闢新的治療途徑.
배경 뇌원성신경영양인자(brain-derived neurotrophic factor,BDNF)시신경영양인자가족최구대표성적성원지일.최근연구표명BDNF역재심혈관계통표체,차여급성심기경사(acute myocardial infarction,AMI)후심기중소밀절상관.목적 분석총결BDNF여AMI후심기중소상관성적문헌자료.내용 종기인다태성、혈관신생、심기세포조망、염증반응,취BDNF여AMI후심기중소상관성가이묘술. 추향 AMI후심기중소BDNF재심기표체명현상조.BDNF이기독특적생물학공능,유망위심기중소개벽신적치료도경.
Background The brain-derived neurotrophic factor is one of the most representative neurotrophic factors.Recent studies showed that brain-derived neurotrophic factor (BDNF) is also expressed in cardiovascular system and is closely related to myocardial remodeling following acute myocardial infarction. Objective This paper summed up literatures on the correlation between BDNF and myocardial remodeling following acute myocardial infarction. Content The relevance of BDNF and myocardial remodeling following acute myocardial infarction, in ways of genetic polymorphism,angiogenesis,apoptotic cardiomyocytes and inflammatory response were discussed. Trend The expression of BDNF in the myocardium significantly increases during myocardial remodeling following acute myocardial infarction.BDNF,due to its unique biological function,is expected to open up a new therapeutic approach for myocardial remodeling.
