中华放射学杂志
中華放射學雜誌
중화방사학잡지
Chinese Journal of Radiology
2010年
7期
747-752
,共6页
彭新桂%居胜红%方芳%滕皋军
彭新桂%居勝紅%方芳%滕皋軍
팽신계%거성홍%방방%등고군
磁共振成像%磁共振波谱学%脂肪类%模型
磁共振成像%磁共振波譜學%脂肪類%模型
자공진성상%자공진파보학%지방류%모형
Magnetic resonance imaging%Magnetic resonance spectroscopy%Fats%Models
目的 评价化学位移成像(chemical shift imaging,CSI)和MRS两种方法在脂肪研究中的作用,为进一步活体实验提供定量标准.方法 在7.0 T MR成像仪上运用CSI和MRS方法对体外水脂模型进行水脂定量分析.体外水脂模型的脂肪含量从0～100%平均分成11个组,各组间浓度相差10%,分别应用水、脂肪选择性CSI和1H-MRS对体外水脂模型进行图像和波谱数据采集,对2种方法所得结果分别与实际水脂含量进行单样本t检验及相关分析并比较两种方法问的相关性.MRS计算100%油模型饱和脂肪酸(fraction of saturated fatty acids,FS)、不饱和脂肪酸(fraction of unsaturated fatty acids,FU)的相对含量及多聚不饱和程度(polyunsaturation degree,PUD).结果 CSI法测定实际脂肪含量为50%～100%的测量值分别为(48.0±1.0)%、(57.0±0.5)%、(67.3±0.6)%、(77.3 ±0.6)%、(83.3±0.6)%和(91.0±1.0)%;MRS测定实际脂肪含量为10%～60%的测量值分别为(8.3±0.6)%、(16.3±0.7)%、(27.7±0.6)%、(36.0±1.0)%、(43.5±0.6)%和(56.5±1.0)%,均轻度低估了脂肪含量,差异均有统计学意义(P值均<0.05).CSI与MRS计算的脂肪含量与实际脂肪含量间均呈线性相关(CSI:r=0.998,MRS:r=0.996;P值均<0.01);两种方法间也呈线性相关(r=0.992,P<0.01),两种方法定量脂肪含量差异无统计学意义(t=-0.125,P:0.903).MRS计算橄榄油的FS和FU相对含量分别为0.15和0.85,PUD为0.0325,与实际含量一致.结论 在7.0 T MR成像仪上,体外水脂模型证实CSI和MRS定量脂肪的准确性及在脂肪研究上的可行性.
目的 評價化學位移成像(chemical shift imaging,CSI)和MRS兩種方法在脂肪研究中的作用,為進一步活體實驗提供定量標準.方法 在7.0 T MR成像儀上運用CSI和MRS方法對體外水脂模型進行水脂定量分析.體外水脂模型的脂肪含量從0～100%平均分成11箇組,各組間濃度相差10%,分彆應用水、脂肪選擇性CSI和1H-MRS對體外水脂模型進行圖像和波譜數據採集,對2種方法所得結果分彆與實際水脂含量進行單樣本t檢驗及相關分析併比較兩種方法問的相關性.MRS計算100%油模型飽和脂肪痠(fraction of saturated fatty acids,FS)、不飽和脂肪痠(fraction of unsaturated fatty acids,FU)的相對含量及多聚不飽和程度(polyunsaturation degree,PUD).結果 CSI法測定實際脂肪含量為50%～100%的測量值分彆為(48.0±1.0)%、(57.0±0.5)%、(67.3±0.6)%、(77.3 ±0.6)%、(83.3±0.6)%和(91.0±1.0)%;MRS測定實際脂肪含量為10%～60%的測量值分彆為(8.3±0.6)%、(16.3±0.7)%、(27.7±0.6)%、(36.0±1.0)%、(43.5±0.6)%和(56.5±1.0)%,均輕度低估瞭脂肪含量,差異均有統計學意義(P值均<0.05).CSI與MRS計算的脂肪含量與實際脂肪含量間均呈線性相關(CSI:r=0.998,MRS:r=0.996;P值均<0.01);兩種方法間也呈線性相關(r=0.992,P<0.01),兩種方法定量脂肪含量差異無統計學意義(t=-0.125,P:0.903).MRS計算橄欖油的FS和FU相對含量分彆為0.15和0.85,PUD為0.0325,與實際含量一緻.結論 在7.0 T MR成像儀上,體外水脂模型證實CSI和MRS定量脂肪的準確性及在脂肪研究上的可行性.
목적 평개화학위이성상(chemical shift imaging,CSI)화MRS량충방법재지방연구중적작용,위진일보활체실험제공정량표준.방법 재7.0 T MR성상의상운용CSI화MRS방법대체외수지모형진행수지정량분석.체외수지모형적지방함량종0～100%평균분성11개조,각조간농도상차10%,분별응용수、지방선택성CSI화1H-MRS대체외수지모형진행도상화파보수거채집,대2충방법소득결과분별여실제수지함량진행단양본t검험급상관분석병비교량충방법문적상관성.MRS계산100%유모형포화지방산(fraction of saturated fatty acids,FS)、불포화지방산(fraction of unsaturated fatty acids,FU)적상대함량급다취불포화정도(polyunsaturation degree,PUD).결과 CSI법측정실제지방함량위50%～100%적측량치분별위(48.0±1.0)%、(57.0±0.5)%、(67.3±0.6)%、(77.3 ±0.6)%、(83.3±0.6)%화(91.0±1.0)%;MRS측정실제지방함량위10%～60%적측량치분별위(8.3±0.6)%、(16.3±0.7)%、(27.7±0.6)%、(36.0±1.0)%、(43.5±0.6)%화(56.5±1.0)%,균경도저고료지방함량,차이균유통계학의의(P치균<0.05).CSI여MRS계산적지방함량여실제지방함량간균정선성상관(CSI:r=0.998,MRS:r=0.996;P치균<0.01);량충방법간야정선성상관(r=0.992,P<0.01),량충방법정량지방함량차이무통계학의의(t=-0.125,P:0.903).MRS계산감람유적FS화FU상대함량분별위0.15화0.85,PUD위0.0325,여실제함량일치.결론 재7.0 T MR성상의상,체외수지모형증실CSI화MRS정량지방적준학성급재지방연구상적가행성.
Objective To evaluate the accuracy of chemical shift imaging (CSI) and MR spectroscopy (MRS) for fat quantification in phantom model. Methods Eleven phantoms were made according to the volume percentage of fat ranging from 0 to 100% with an interval of 10% . The fat concentration in the phantoms were measured respectively by CSI and MRS and compared using one-sample t test The correlation between the two methods was also analyzed. The concentration of saturated fatty acids ( FS), unsaturated fatty acids (FU) and the polyunsaturation degree (PUD) were calculated by using MRS. Results The fat concentration was (48.0 ±1.0)%, (57.0 ±0.5)%, (67.3±0.6)%, (77.3 ±0.6)%, (83.3±0.6)% and (91.0±1.0)% respectively with fat volume of 50% to 100% by CSI. The fat concentration was (8.3 ±0.6)%, (16.3 ±0.7)%, (27.7 ±0.6)%, (36.0 ±1.0)%, (43.5±0. 6)% and (56. 5 ±1. 0)% respectively with fat volume of 10% to 60% by MRS, the fat concentration were underestimated by CSI and MRS (P < 0.05 ), and had high linear correlation with the real concentration in phantoms ( CSI: r = 0. 998, MRS: r = 0.996, P < 0.01 ) . There was also a linear correlation between two methods (r = 0. 992, P < 0. 01 ) but no statistically significant difference ( pairedsamples t test, t = -0. 125 ,P = 0.903). By using MRS, the relative ratio of FS and FU in fat were 0. 15and 0. 85, the PUD was 0. 0325, respectively, and highly consistent with these in phantoms. Conclusion Both CSI and MRS are efficient and accurate methods in fat quantification at 7.0 T MR.
