CAJ | 학술논문

目的定量分析中心性浆液性脉络膜视网膜病变(CSC)患者黄斑中心凹下脉络膜厚度改变.方法横断面研究.选择经荧光素眼底血管造影(FFA)、吲哚氰绿血管造影(ICGA)、脉络膜深层成像相干光断层扫描(EDI-OCT)检查后,确诊的23例单眼CSC患者作为研究对象；以年龄、性别、屈光状态与CSC组相匹配的23例正常人作为对照.应用EDI-OCT技术及仪器内白带软件检测患者组和对照组黄斑中心凹下脉络膜厚度.患者组患眼与对侧眼脉络膜厚度比较,采用配对t检验;患者组患眼和对侧眼脉络膜厚度分别与对照组比较(非正态分布),采用独立样本秩和检验,并以Bonferroni法进行校正.结果 CSC患者组的患眼黄斑中心凹下脉络膜厚度为(464.43±97.15)μm,对侧眼为(399.91±124.01) μm,两者差异有统计学意义(t=4.653,P＜0.05).正常对照组黄斑中心凹下脉络膜厚度为(313.09±70.67)μm,患者组的患眼和对侧眼脉络膜厚度分别与正常对照组比较,差异有统计学意义(t=5.077,-2.085;P ＜0.05).患眼的对侧眼中ICGA高灌注眼脉络膜厚度为(506.44±75.66) μm,非高灌注眼为(331.43±97.94) μm,两者差异有统计学意义(t=4.749,P＜0.05).结论 CSC患者的患眼脉络膜厚度较对侧眼及对照组增厚,对侧眼中ICGA高灌注眼的脉络膜厚度较非高灌注眼增厚.EDI-OCT检测技术是观察脉络膜血管通透性改变的无损伤手段之一.
목적 정량분석중심성장액성맥락막시망막병변(CSC)환자황반중심요하맥락막후도개변.방법 횡단면연구.선택경형광소안저혈관조영(FFA)、신타청록혈관조영(ICGA)、맥락막심층성상상간광단층소묘(EDI-OCT)검사후,학진적23례단안CSC환자작위연구대상；이년령、성별、굴광상태여CSC조상필배적23례정상인작위대조.응용EDI-OCT기술급의기내백대연건검측환자조화대조조황반중심요하맥락막후도.환자조환안여대측안맥락막후도비교,채용배대t검험;환자조환안화대측안맥락막후도분별여대조조비교(비정태분포),채용독립양본질화검험,병이Bonferroni법진행교정.결과 CSC환자조적환안황반중심요하맥락막후도위(464.43±97.15)μm,대측안위(399.91±124.01) μm,량자차이유통계학의의(t=4.653,P＜0.05).정상대조조황반중심요하맥락막후도위(313.09±70.67)μm,환자조적환안화대측안맥락막후도분별여정상대조조비교,차이유통계학의의(t=5.077,-2.085;P ＜0.05).환안적대측안중ICGA고관주안맥락막후도위(506.44±75.66) μm,비고관주안위(331.43±97.94) μm,량자차이유통계학의의(t=4.749,P＜0.05).결론 CSC환자적환안맥락막후도교대측안급대조조증후,대측안중ICGA고관주안적맥락막후도교비고관주안증후.EDI-OCT검측기술시관찰맥락막혈관통투성개변적무손상수단지일.
Objective To determine the quantitative changes of choroidal thickness in central serous chorioretinopathy.Methods Cross-sectional study.Twenty-three patients with unilateral central serous chorioretinopathy (CSC) in acute and chronic stages were diagnosed after fluorescein angiography,indocyanine angiography and enhanced depth imaging optical coherence tomography (EDI OCT).EDI OCT scan across the fovea was performed in each eye and the result was compared with that from an age-,sex-matched and spherical equivalent-matched control subject.Subfoveal thickness of choroid was calculated by a onboard software in HRA2.Results Choroidal thickness in the CSC eyes and the fellow eyes was (464.43 ±97.15) μm and (399.91 ± 124.01) μm,respectively.No significant difference between the two groups (t =4.653,P ＜ 0.05).Choroidal thickness was (313.09 ± 70.67)μm in the control group.There was statistically significant difference in thickness between the CSC goup and the control group (t =5.077,-2.085 ;P ＜ 0.05).Choroidal thickness in the fellow eyes with choroidal vascular hyperpermeability was (506.44 ± 75.66) μm,which was differed significantly(t =4.749,P ＜ 0.05) from the non-hypermeability eyes (331.43 ±97.94)μm.Conclusions Subfoveal choroid thickness in the symptomatic eye and the fellow eyes in CSC gruoup is thicker than that of the control group.The subfoveal choroidal thickness of eyes with hypermeability is thicker than that in the non-hypermeability eyes.EDI-OCT is a noninvasive procedure which can be used to evaluate the choroidal hypermeability in CSC.