中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2008年
27期
1892-1895
,共4页
邵晓凤%苏茵%代琛贤%栗占国
邵曉鳳%囌茵%代琛賢%慄佔國
소효봉%소인%대침현%률점국
红斑狼疮,系统性%相关因素%诊断
紅斑狼瘡,繫統性%相關因素%診斷
홍반랑창,계통성%상관인소%진단
Lupus erythematosus,systemic%Factor,related%Diagnosis
目的 探讨系统性红斑狼疮(SLE)患者发病相关因素及发病后就诊情况.方法 随访203例SLE患者,其中女192例,男11例,男女之比为1:17,平均发病年龄(32±14)岁,平均病程3年,了解其发病前的各种相关诱因、家族史、发病后诊断及用药情况等,并进行统计学分析.结果 因发病前曾经有劳累病史的患者63例,有先驱感染病史的患者47例,分别占调查者的31.0%和23.2%;日晒、情绪波动、月经紊乱、流产、染发、接触化学药物,分别占调查者的14.3%、14.3%、9.4%、6.9%、4.9%和1.5%;16例患者(7.9%)有阳性家族史;首诊即明确诊断的患者有120例,占调查人数的59.1%;另有83例患者误诊,其中23.2%的患者发病1年后仍没有得到正确诊断,误诊最长时间为14年;69.0%的患者确诊后首次用药选择糖皮质激素及免疫抑制剂,19.2%首选中药或者偏方治疗;发病后128例患者不能正常工作.结论 SLE患者女性多发,劳累、感染、日晒、情绪波动等因素与SLE发病中有一定的相关性,诱发因素多种多样;发病后不能及时得到正确诊断和治疗的SLE患者仍占相当大比例;SLE影响患者生活质量的情况较严重.
目的 探討繫統性紅斑狼瘡(SLE)患者髮病相關因素及髮病後就診情況.方法 隨訪203例SLE患者,其中女192例,男11例,男女之比為1:17,平均髮病年齡(32±14)歲,平均病程3年,瞭解其髮病前的各種相關誘因、傢族史、髮病後診斷及用藥情況等,併進行統計學分析.結果 因髮病前曾經有勞纍病史的患者63例,有先驅感染病史的患者47例,分彆佔調查者的31.0%和23.2%;日曬、情緒波動、月經紊亂、流產、染髮、接觸化學藥物,分彆佔調查者的14.3%、14.3%、9.4%、6.9%、4.9%和1.5%;16例患者(7.9%)有暘性傢族史;首診即明確診斷的患者有120例,佔調查人數的59.1%;另有83例患者誤診,其中23.2%的患者髮病1年後仍沒有得到正確診斷,誤診最長時間為14年;69.0%的患者確診後首次用藥選擇糖皮質激素及免疫抑製劑,19.2%首選中藥或者偏方治療;髮病後128例患者不能正常工作.結論 SLE患者女性多髮,勞纍、感染、日曬、情緒波動等因素與SLE髮病中有一定的相關性,誘髮因素多種多樣;髮病後不能及時得到正確診斷和治療的SLE患者仍佔相噹大比例;SLE影響患者生活質量的情況較嚴重.
목적 탐토계통성홍반랑창(SLE)환자발병상관인소급발병후취진정황.방법 수방203례SLE환자,기중녀192례,남11례,남녀지비위1:17,평균발병년령(32±14)세,평균병정3년,료해기발병전적각충상관유인、가족사、발병후진단급용약정황등,병진행통계학분석.결과 인발병전증경유로루병사적환자63례,유선구감염병사적환자47례,분별점조사자적31.0%화23.2%;일쇄、정서파동、월경문란、유산、염발、접촉화학약물,분별점조사자적14.3%、14.3%、9.4%、6.9%、4.9%화1.5%;16례환자(7.9%)유양성가족사;수진즉명학진단적환자유120례,점조사인수적59.1%;령유83례환자오진,기중23.2%적환자발병1년후잉몰유득도정학진단,오진최장시간위14년;69.0%적환자학진후수차용약선택당피질격소급면역억제제,19.2%수선중약혹자편방치료;발병후128례환자불능정상공작.결론 SLE환자녀성다발,로루、감염、일쇄、정서파동등인소여SLE발병중유일정적상관성,유발인소다충다양;발병후불능급시득도정학진단화치료적SLE환자잉점상당대비례;SLE영향환자생활질량적정황교엄중.
Objective To investigate the related factors of systemic 1upus erythematosus(SLE)and the situatjon of diagnosis and treatment after onset.Methods 203 SLE patients,11 males and 192 females,with a male/femaIe ratio of 1:17,average onset age of(32±14),and average course of 3 years,were followed up and the related flactors such as risk factors,family history and the situation of diagnosis and treatment were studied.Results 63 patients(31%)had the history of overworking before falling ill;47 patients(23.2%)had suffered from infection before SLE onset Other risk factors,such as solarization,emotional nuctuation, menstmal disorder,abortion,dyeing, and chemical drug contacting accounted for14.3%,14.3%,9.4%,6.9%,4.9%,and 1.5%respectively.16 patients(7.9%)had positive family history. 120 patients got the correct diagnosis at the first visit 83 patients had been misdiagnosed for less than 1 year to 14 years.47 of the 83 patients(23.2%)failed to get the correct diagnosis for more than one year 140 of the 203 patiens(69.0%)were given glucocorticoid and/or immunosuppressant as the first choice treatment measures after the diagnosis was confirmed. 39 of the 203 patjents (19.2%) chose traditional Chinese medicine or folk prescription as the first choice. And 24 of the 203 patients(11.8%)used anti-innarnmatory, and antipyretic drugs. 128 patients (63.1%) failed to continue to work.ConcIusion overworking,infection,solarization,and emotional fluctuation may be related to the onset of SLE.A great part of SLE patients can not be diagnosed early and treated promply.SLE brings bad influence on the life quality of patients.
