CAJ | 학술논문

目的观察冠心病患者血清视黄醇结合蛋白4(RBP4)水平,并探讨RBP4与冠心病的关系.方法 64例冠心病患者分为急性心肌梗死(AMI)组10例,不稳定型心绞痛(UAP)组42例,稳定型心绞痛(SAP)组12例,另选择21例冠状动脉造影结果正常者为对照组.采用酶联免疫吸附法(ELISA)测定血清RBP4水平.结果血清RBP4在AMI和UAP组中高于SAP组和对照组,差异有统计学意义(P＜0.05),在SAP组与对照组之间差异无统计学意义(P＞0.05);血清RBP4在单支、双支、三支病变组中均高于对照组(P＜0.05),但在单支、双支与三支病变组之间差异均无统计学意义(P＞0.05).结论 RBP4可作为预测斑块稳定性的标志物,为冠心病危险分层及采取积极干预措施提供依据,但不能反映冠状动脉狭窄程度及范围.
목적 관찰관심병환자혈청시황순결합단백4(RBP4)수평,병탐토RBP4여관심병적관계.방법 64례관심병환자분위급성심기경사(AMI)조10례,불은정형심교통(UAP)조42례,은정형심교통(SAP)조12례,령선택21례관상동맥조영결과정상자위대조조.채용매련면역흡부법(ELISA)측정혈청RBP4수평.결과 혈청RBP4재AMI화UAP조중고우SAP조화대조조,차이유통계학의의(P＜0.05),재SAP조여대조조지간차이무통계학의의(P＞0.05);혈청RBP4재단지、쌍지、삼지병변조중균고우대조조(P＜0.05),단재단지、쌍지여삼지병변조지간차이균무통계학의의(P＞0.05).결론 RBP4가작위예측반괴은정성적표지물,위관심병위험분층급채취적겁간예조시제공의거,단불능반영관상동맥협착정도급범위.
Objective To investigate the serum retinol - binding protein 4 ( RBP 4 ) of coronary heart disease (CHD)patients and evaluate whether plasma macrophage migration inhibitory factor were associated with CHD. Methods Sixty -four patients with CHD were divided into the acute myocardial infarction (AMI) group ( n = 10), the unstable angina pectoris (UAP) group ( n = 42) and the stable angina pectoris(SAP) ( n = 12),21 normal subjests without CHD diagnosed by CAG served as the control group. The serum level of RBP4 measured by enzyme linked immune sorbent assay (ELISA). Results The serum level of RBP4 were higher in AMI and UAP group thai in SAP group and control group ( P ＜ 0. 05 ). The mean level of RBP4 in SAP group was not differently significantly, compared with that in control ( P ＞ 0. 05 ) ;The mean level of in single, double and three vessel lesion group were higher than that in control group (P ＜0. 05 ),but the serum levels of RBP4 among single, double and three were not significant different ( P ＞ 0. 05).Conclusions RBP4 may act as one of vulnerable plaques,we can take active to stabilize vulnerable plaques and decrease the occurrence of cardiac events,but may not reflect the severity of artery stenosis.