CAJ | 학술논문

目的探讨腋淋巴结切除数目与腋淋巴结阴性乳腺癌患者预后的关系.方法对655例原发性乳腺癌且腋淋巴结阴性患者的临床资料进行回顾性分析,根据腋淋巴结切除数目绘制Kaplan-Meier生存曲线,以Cox比例风险模型分析腋淋巴结切除数目以及其他预后因素与乳腺癌相关事件发生率之间的关系.结果全组655例患者的5年无病生存率为94.4％,其中腋淋巴结切除≤12个和＞12个患者的5年无病生存率分别为90.3％和96.5％,差异有统计学意义(P=0.009).腋淋巴结切除＞12个时,乳腺癌相关事件的发生率明显下降(P=0.009).结论在腋淋巴结清扫术中,淋巴结切除＞12个的患者发生乳腺癌相关事件的比例远低于淋巴结切除≤12个的患者；淋巴结切除数目越多,对预后的判断越准确.
목적 탐토액림파결절제수목여액림파결음성유선암환자예후적관계.방법 대655례원발성유선암차액림파결음성환자적림상자료진행회고성분석,근거액림파결절제수목회제Kaplan-Meier생존곡선,이Cox비례풍험모형분석액림파결절제수목이급기타예후인소여유선암상관사건발생솔지간적관계.결과 전조655례환자적5년무병생존솔위94.4％,기중액림파결절제≤12개화＞12개환자적5년무병생존솔분별위90.3％화96.5％,차이유통계학의의(P=0.009).액림파결절제＞12개시,유선암상관사건적발생솔명현하강(P=0.009).결론 재액림파결청소술중,림파결절제＞12개적환자발생유선암상관사건적비례원저우림파결절제≤12개적환자；림파결절제수목월다,대예후적판단월준학.
Objective To analyze the relationship between the number of removed axillary lymph nodes and prognosis of axillary node-negative breast cancer.Methods The clinicopathological data of 655 patients with breast cancer were analyzed retrospectively.The disease-free survival curves were generated according to the number of removed axillary lymph nodes using Kaplan-Meier plots.The correlation between the co-variables and rate of breast cancer-related events was analyzed using Cox model.Results The overall five year-disease free survival rate of the 655 cases was 94.4％.The rate of patients with lymph node number ≤12 was 90.3％,and that of lymph node number ＞12 was96.5％,with a statistically significant difference ( P =0.009).Significantly less breast cancer-relaned events were observed in patients with lymph node number ＞12 (15/426,3.5％) than that in patients with lymph node number ≤12 (22/229,9.6％)(P=0.009).Conclusions When axillary nodec dissection is indicated,dissection of lymph nodes ＞12leads to much less breast cancer-related events than that in patients with dissected lymph node ≤ 12.The more lymph nodes are dissected,the more accurate prognosis can be estimated.