CAJ | 학술논문

免疫异常与神经递质改变是抑郁症产生的十分重要的因素.近年来,免疫激活产生的细胞因子对抑郁症病理过程的干预作用已成为众多学者研究的热点,亦是新型抗抑郁药的潜在靶点.免疫激活能导致谷氨酸系统和五羟色胺系统的紊乱,该文对此干预作用作一综述.
면역이상여신경체질개변시억욱증산생적십분중요적인소.근년래,면역격활산생적세포인자대억욱증병리과정적간예작용이성위음다학자연구적열점,역시신형항억욱약적잠재파점.면역격활능도치곡안산계통화오간색알계통적문란,해문대차간예작용작일종술.
Immunological alterations and changes in neurotransmission are considered to be crucial in the pathological process of depression. An immune activation including increased production of proinflammatory cytokines has repeatedly been described in depression, which shines a clue for new anti-depression therapy. Immune activation will lead to depression through serotonin and glutamate systems. This paper is attempted to review the immune mediated alterations on serotonin and glutamate systems.