CAJ | 학술논문

目的将氨基葡萄糖与硫酸软骨素制威复方片剂,考察其抗炎与镇痛作用.方法氨基葡萄糖与硫酸软骨素按5:4的比例压片制成复方片剂.以SD大鼠为实验动物,建立足趾肿胀模型进行抗急性炎症实验;采用棉球植入法进行抗慢性炎症实验;以ICR小鼠为实验动物,建立小鼠疼痛模型进行镇痛实验.结果给药28 d,足趾肿胀1 h.低、中、高剂量组足趾肿胀度明显小于正常对照组(P<0.05).大鼠肉芽肿实验结果显示各给药组与正常组相比能明显抑制大鼠肉芽肿(P<0.05).醋酸致小鼠扭体实验显示各给药组与对照组比较,对醋酸致小鼠扭体次数有明显的抑制(P<0.05).结论氨基葡萄糖与硫酸软骨素复方片具有抗炎作用;对醋酸致小鼠疼痛模型具有镇痛作用.
목적 장안기포도당여류산연골소제위복방편제,고찰기항염여진통작용.방법 안기포도당여류산연골소안5:4적비례압편제성복방편제.이SD대서위실험동물,건립족지종창모형진행항급성염증실험;채용면구식입법진행항만성염증실험;이ICR소서위실험동물,건립소서동통모형진행진통실험.결과 급약28 d,족지종창1 h.저、중、고제량조족지종창도명현소우정상대조조(P<0.05).대서육아종실험결과현시각급약조여정상조상비능명현억제대서육아종(P<0.05).작산치소서뉴체실험현시각급약조여대조조비교,대작산치소서뉴체차수유명현적억제(P<0.05).결론 안기포도당여류산연골소복방편구유항염작용;대작산치소서동통모형구유진통작용.
Purpose The glucosamine and chondroitin compound tablets were prepared. The anti-inflammatory and analgesic effects of glucosamine and chondrotin compound tablets were investigated. Methods The proportion of glucosamine and chondroitin was 5:4 to prepare compound tablets. The anti-inflammatory effect was investigated with carrageen-induced rats paw edema and cotton granuloma in rats. The analgesic effect was investigated using the pain models of mice which were induced by 0.6% acetic acid. Results Compared with control group the degree of paw edema in the low, middle and high dose group was decreased ( P < 0.05). Fourtreatment groups compared with control group respectively at the weight of granuloma were also markedly reduced ( P < 0.05) and the writhing number of mice induced by acetic acid was decreased ( P < 0.05 ) . Conclusion glucosamine and chondroitin compound tablets have anti-inflammatory effect and analgesic effect on models induced by acetic acid.