CAJ | 학술논문

目的观察肠结核患者用胸腺肽-α1治疗前后外周血T细胞亚群、NK细胞的变化.方法 66例肠结核患者在常规抗结核治疗基础上,加用胸腺肽-α1治疗,采用流式细胞术检测治疗前后外周血T细胞亚群及NK细胞的水平;62例常规抗结核治疗的肠结核患者作为对照组.结果 66例患者在治疗12,16周后,CD3~+、CD4~+、CD8~+、CD4~+/CD8~+检测值均较治疗前明显增高(P<0.05);NK细胞在治疗第8,12,16周均显著性增高(P<0.05);而对照组患者则治疗前后差异无显著性(P>0.05);且试验组临床疗效较好(P<0.05).结论胸腺肽-α1能够显著改善肠结核患者的机体免疫功能状态.
목적 관찰장결핵환자용흉선태-α1치료전후외주혈T세포아군、NK세포적변화.방법 66례장결핵환자재상규항결핵치료기출상,가용흉선태-α1치료,채용류식세포술검측치료전후외주혈T세포아군급NK세포적수평;62례상규항결핵치료적장결핵환자작위대조조.결과 66례환자재치료12,16주후,CD3~+、CD4~+、CD8~+、CD4~+/CD8~+검측치균교치료전명현증고(P<0.05);NK세포재치료제8,12,16주균현저성증고(P<0.05);이대조조환자칙치료전후차이무현저성(P>0.05);차시험조림상료효교호(P<0.05).결론 흉선태-α1능구현저개선장결핵환자적궤체면역공능상태.
Objective To investigate the changes of T-lymphocyte subsets, NK cells and clinical signification in patients with intestinal tu-berculosis after the treatment of thymosin-al. Methods Sixty-six ca-ses of intestinal tuberculosis patients were treated by thymosin-α1 fol-lowed the basis of conventional anti-TB treatment, while 62 cases as a control group. The frequencies of peripheral blood T-lymphocyte subsets and NK cells were determined by flow cytometry. Results After the end of 12 and 16 weeks, the values of CD3~+ , CD4~+ , CD8~+ , and CD4~+/CD8~+ in trial group exhibited significantly higher than that before treat-ment (P<0.05). NK cells in the end of 8, 12, and 16 weeks showed an ascension too (P < 0. 05). There was no significant difference in the control group after treatment (P > 0. 05). The better clinical efficacy was found in the trial group (P < 0. 05). Conclusion Thymosin-α1 can significantly improve the intestinal immunolologic function in the patient with tuberculosis infection.