CAJ | 학술논문

目的探讨重型颅脑损伤患者应用质子泵抑制剂(PPI)预防应激性溃疡后是否增加院内获得性肺炎的发生率.方法回顾性调查近1年来我院收治的120例住院时间大于7天的重型颅脑损伤患者资料,分析使用PPI与未使用者发生院内获得性肺炎的情况.结果在120例重型颅脑损伤患者中使用PPI者83例,发生院内获得性肺炎29例,感染率为34.94％,尤其持续使用PPI≥7天者感染率为47.05％;未使用者34例,发生院内获得性肺炎4例,感染率为10.81％.结论应用PPI预防应激性溃疡的重型颅脑损伤患者院内获得性肺炎发生率明显高于未使用者,长时间持续使用明显高于短时使用.临床应根据患者具体情况选择用药和控制用药时间,以减少院内获得性肺炎发生率,减轻患者痛苦,减少资源浪费.
목적 탐토중형로뇌손상환자응용질자빙억제제(PPI)예방응격성궤양후시부증가원내획득성폐염적발생솔.방법 회고성조사근1년래아원수치적120례주원시간대우7천적중형로뇌손상환자자료,분석사용PPI여미사용자발생원내획득성폐염적정황.결과 재120례중형로뇌손상환자중사용PPI자83례,발생원내획득성폐염29례,감염솔위34.94％,우기지속사용PPI≥7천자감염솔위47.05％;미사용자34례,발생원내획득성폐염4례,감염솔위10.81％.결론 응용PPI예방응격성궤양적중형로뇌손상환자원내획득성폐염발생솔명현고우미사용자,장시간지속사용명현고우단시사용.림상응근거환자구체정황선택용약화공제용약시간,이감소원내획득성폐염발생솔,감경환자통고,감소자원낭비.
Objective To investigate whether using proton pump inhibitors (PPI) to prevent stress ulceration increase the incidence of hospital acquired pneumonia (HAP) in severe craniocerebral injury patients.Methods 120 case with severe craniocerebral injury for more than 7 days in our hospital in recent one year were analyzed and compared the incidence of HAP between using PPI and not.Results There were 83 cases using PPI in 120 cases of severe craniocerebral injury and 29 occurring HAP.The infection rate was 34.94％,especially with continued use ≥ 7days it was 47.05％.There were 34 cases without using PPI,4 found occurring HAP.The infection rate was 10.81％.Conclusions The incidence rate of HAP in patients with severe craniocerebral injury using PPI is significantly higher than that of those without using PPI.And incidence rate of HAP in the long-term use of PPI is obviously higher than the short-term one.The clinical doctors should choose drug and control drug using time according to the specific situation of patients,to reduce the incidence of HAP,and relieve pain of patients and reduce waste of resources.