中华胰腺病学杂志
中華胰腺病學雜誌
중화이선병학잡지
CHINESE JOURNAL OF PANCREATOLOGY
2008年
2期
78-80
,共3页
周国中%吕礁%施云星%李永平%郑智武%刘长云%金冠球
週國中%呂礁%施雲星%李永平%鄭智武%劉長雲%金冠毬
주국중%려초%시운성%리영평%정지무%류장운%금관구
胰腺肿瘤%放射疗法%γ射线%VEGF
胰腺腫瘤%放射療法%γ射線%VEGF
이선종류%방사요법%γ사선%VEGF
Pancreatic neoplasms%Radiotherapy%Gamma rays%VEGF
目的 分析血管内皮生长因子(VEGF)水平与伽玛刀治疗胰腺癌疗效的关系,探讨其临床意义.方法 检测30例胰腺癌患者伽玛刀治疗前和治疗1个月后VEGF水平,分析其与疗效、患者生存期、生活质量的关系.结果 胰腺癌患者伽玛刀治疗前血清VEGF为(624.1±144.3)pg/ml,治疗1个月后为(279.3±83.4)pg/ml(P＜0.01).VEGF含量下降≥50%的19例中,CR+PR 18例,生活质量改善7例;VEGF下降＜50%的11例中,CR+PR 7例,生活质量改善1例,两组相差显著(P=0.012,P=0.028).随访满2年的24例患者中,VEGF下降≥50%的15例,1年生存率73.3%(11/15),显著高于VEGF下降＜50%者的22.2%(2/9,P＜0.033).结论 伽玛刀治疗后胰腺癌患者血清VEGF水平下降,其下降幅度可作为评价疗效的指标.
目的 分析血管內皮生長因子(VEGF)水平與伽瑪刀治療胰腺癌療效的關繫,探討其臨床意義.方法 檢測30例胰腺癌患者伽瑪刀治療前和治療1箇月後VEGF水平,分析其與療效、患者生存期、生活質量的關繫.結果 胰腺癌患者伽瑪刀治療前血清VEGF為(624.1±144.3)pg/ml,治療1箇月後為(279.3±83.4)pg/ml(P＜0.01).VEGF含量下降≥50%的19例中,CR+PR 18例,生活質量改善7例;VEGF下降＜50%的11例中,CR+PR 7例,生活質量改善1例,兩組相差顯著(P=0.012,P=0.028).隨訪滿2年的24例患者中,VEGF下降≥50%的15例,1年生存率73.3%(11/15),顯著高于VEGF下降＜50%者的22.2%(2/9,P＜0.033).結論 伽瑪刀治療後胰腺癌患者血清VEGF水平下降,其下降幅度可作為評價療效的指標.
목적 분석혈관내피생장인자(VEGF)수평여가마도치료이선암료효적관계,탐토기림상의의.방법 검측30례이선암환자가마도치료전화치료1개월후VEGF수평,분석기여료효、환자생존기、생활질량적관계.결과 이선암환자가마도치료전혈청VEGF위(624.1±144.3)pg/ml,치료1개월후위(279.3±83.4)pg/ml(P＜0.01).VEGF함량하강≥50%적19례중,CR+PR 18례,생활질량개선7례;VEGF하강＜50%적11례중,CR+PR 7례,생활질량개선1례,량조상차현저(P=0.012,P=0.028).수방만2년적24례환자중,VEGF하강≥50%적15례,1년생존솔73.3%(11/15),현저고우VEGF하강＜50%자적22.2%(2/9,P＜0.033).결론 가마도치료후이선암환자혈청VEGF수평하강,기하강폭도가작위평개료효적지표.
Objective To analyze the relationship between the change of serum vascular epidermis growth factor(VEGF) level and curative effect of pancreatic cancer treated by gamma rays, and evaluate it clinical significance. Methods The serum VEGF level of thirty patients with pancreatic cancer treated by gamma rays were determined before and one month after treatment. The relationship between curative effect,survival, life quality and the serum VEGF level was analyzed. Results The serum VEGF level of 30 cases before treatment was (624.1 ± 144.3) pg/ml, whereas one month after treatment it was (279.3 ± 83.4) pg/ml(P ＜0.01 ). In the 19 patient whose serum VEGF level decreased by more than 50%, CR + PR was gained in 18 patients, improved quality of life in 7 patients, and in the 11 patient whose serum VEGF level decreased by less than 50%, CR + PR in 7 patients, improved quality of life in 1 patient( P = 0.012, P = 0. 028). In 24patients who completed 2 years follow-up, 11 of 15 patients whose serum VEGF level decreased by more than 50% survived more than 1 year, which was higher than that of the patients whose serum VEGF level decreased by less than 50%. Conclusions The serum VEGF level decreased significantly after gamma rays treatment and the extent of decrease could be used as a surrogate to evaluate the therapeutic efficacy.
