中华创伤杂志
中華創傷雜誌
중화창상잡지
Chinese Journal of Traumatology
2010年
11期
1043-1046
,共4页
李钢%符伟军%洪宝发%蔡伟%王忠新%曹磊%徐福强%刘自来%崔福斋%宋强%张旭
李鋼%符偉軍%洪寶髮%蔡偉%王忠新%曹磊%徐福彊%劉自來%崔福齋%宋彊%張旭
리강%부위군%홍보발%채위%왕충신%조뢰%서복강%류자래%최복재%송강%장욱
火器%输尿管%支架%膀胱输尿管反流
火器%輸尿管%支架%膀胱輸尿管反流
화기%수뇨관%지가%방광수뇨관반류
Firearms%Ureter%Stents%Vesico-ureteral reflux
目的 建立一种新的输尿管战创伤动物模型,研究生物可降解输尿管支架在输尿管战创伤治疗中对肾功能的保护作用.方法 使用自行研制的火器弹片伤制造模具,对模型建立组9只比格犬的随机一侧输尿管制造火器弹片伤后清创缝合,分别于术后40,80,120 d进行静脉肾盂造影、肾图评估.再对阳性对照组9只比格犬的双侧输尿管均制造火器弹片伤,随机一侧放置聚乳酸可降解输尿管支架,另一侧放置双J管,对其结果进行评估.结果 模型建立组损伤侧术后出现肾积水,肾脏浓聚,排泄功能下降.阳性对照组术后双侧均未见明显肾盂、输尿管积水;双肾分浓缩率比值(可降解支架/双J管)上升,半排时间比值(可降解支架/双J管)上升,但差异均无统计学意义;可降解支架侧未见膀胱输尿管反流(vesico-ureteral reflux,VUR),双J管侧有反流.结论 成功建立了比格犬火器弹片伤动物模型.可降解支架与双J管均起到了支撑、引流作用;可降解支架可有效保护输尿管膀胱交界处的抗反流功能.
目的 建立一種新的輸尿管戰創傷動物模型,研究生物可降解輸尿管支架在輸尿管戰創傷治療中對腎功能的保護作用.方法 使用自行研製的火器彈片傷製造模具,對模型建立組9隻比格犬的隨機一側輸尿管製造火器彈片傷後清創縫閤,分彆于術後40,80,120 d進行靜脈腎盂造影、腎圖評估.再對暘性對照組9隻比格犬的雙側輸尿管均製造火器彈片傷,隨機一側放置聚乳痠可降解輸尿管支架,另一側放置雙J管,對其結果進行評估.結果 模型建立組損傷側術後齣現腎積水,腎髒濃聚,排洩功能下降.暘性對照組術後雙側均未見明顯腎盂、輸尿管積水;雙腎分濃縮率比值(可降解支架/雙J管)上升,半排時間比值(可降解支架/雙J管)上升,但差異均無統計學意義;可降解支架側未見膀胱輸尿管反流(vesico-ureteral reflux,VUR),雙J管側有反流.結論 成功建立瞭比格犬火器彈片傷動物模型.可降解支架與雙J管均起到瞭支撐、引流作用;可降解支架可有效保護輸尿管膀胱交界處的抗反流功能.
목적 건립일충신적수뇨관전창상동물모형,연구생물가강해수뇨관지가재수뇨관전창상치료중대신공능적보호작용.방법 사용자행연제적화기탄편상제조모구,대모형건립조9지비격견적수궤일측수뇨관제조화기탄편상후청창봉합,분별우술후40,80,120 d진행정맥신우조영、신도평고.재대양성대조조9지비격견적쌍측수뇨관균제조화기탄편상,수궤일측방치취유산가강해수뇨관지가,령일측방치쌍J관,대기결과진행평고.결과 모형건립조손상측술후출현신적수,신장농취,배설공능하강.양성대조조술후쌍측균미견명현신우、수뇨관적수;쌍신분농축솔비치(가강해지가/쌍J관)상승,반배시간비치(가강해지가/쌍J관)상승,단차이균무통계학의의;가강해지가측미견방광수뇨관반류(vesico-ureteral reflux,VUR),쌍J관측유반류.결론 성공건립료비격견화기탄편상동물모형.가강해지가여쌍J관균기도료지탱、인류작용;가강해지가가유효보호수뇨관방광교계처적항반류공능.
Objective To establish a new canine model of ureter trauma to observe the protective effect of biodegradable ureteral stent on renal function following traumatic ureter injury. Methods A self-made device was used to make firearm fragment wounds unilaterally on the ureters in nine Beagle dogs (model group). The wounds were debrided and sutured and the results were evaluated by using intravenous pyelography (IVP) and radioactive renography at 40, 80 and 120 days postoperatively. Firearm fragment wounds were made to the bilateral ureters of nine Beagle dogs in the positive control group, in which a biodegradable stent was placed in one side and a double-J stent placed in the other side. Results In model group, hydronephrosis and hydroureter occurred and got worse postoperatively on the wounded side in all nine Beagle dogs, while none of these symptoms were found in any animals in the control group. The ratios of biodegradable stent side to double-J stent side were increased in renal patial concertration index and half time of kidney washout, but neither showed significant differences. However,vesicoureteral reflux (VUR) was not found in the biodegradable stent side, but in the double -J stent side. Conclusions A new canine model of firearm fragment wounds is successfully developed. Both the biodegradable and double-J stent play important roles in support and drainage and show no significant difference in aspects of renal uptake and half time of kidney washout. The biodegradable stent can effectively prevent VUR.
