CAJ | 학술논문

目的探讨脆性组氨酸三联体基因蛋白(fragile histidine triad,FHIT)、纤黏连蛋白(fibronectin,FN)、张力蛋白同源基因蛋白(phosphatase and tensin homology deleted on chromosome ten,PTEN)在肝癌组织中的表达及与患者预后的关系.方法应用免疫组化方法检测138例肝癌组织标本的FHIT,FN,PTEN的表达情况,分析表达与患者临床病理因素的关系.差异检验采用Log-rank检验.结果 FHIT,FN,PTEN在肝癌组织中的表达与癌旁组织比较差异有统计学意义(分别x2=5.968,7.380,4.962,均P＜0.05),与肿瘤大小,分化程度,肿瘤数目,淋巴结转移,癌栓形成等比较差异有统计学意义(P＜0.05),FHIT,FN表达阳性患者组较阴性患者组生存时间短(分别x2=4.443,9.867;均P＜0.05),而PTEN表达阳性患者较阴性患者生存时间长(分别x2=4.199,P＜0.05).结论 FHIT,FN,PTEN在肝癌组织中存在异常表达,FHTT,FN表达提示患者预后不良,PTEN表达提示患者预后较好.
목적 탐토취성조안산삼련체기인단백(fragile histidine triad,FHIT)、섬점련단백(fibronectin,FN)、장력단백동원기인단백(phosphatase and tensin homology deleted on chromosome ten,PTEN)재간암조직중적표체급여환자예후적관계.방법 응용면역조화방법검측138례간암조직표본적FHIT,FN,PTEN적표체정황,분석표체여환자림상병리인소적관계.차이검험채용Log-rank검험.결과 FHIT,FN,PTEN재간암조직중적표체여암방조직비교차이유통계학의의(분별x2=5.968,7.380,4.962,균P＜0.05),여종류대소,분화정도,종류수목,림파결전이,암전형성등비교차이유통계학의의(P＜0.05),FHIT,FN표체양성환자조교음성환자조생존시간단(분별x2=4.443,9.867;균P＜0.05),이PTEN표체양성환자교음성환자생존시간장(분별x2=4.199,P＜0.05).결론 FHIT,FN,PTEN재간암조직중존재이상표체,FHTT,FN표체제시환자예후불량,PTEN표체제시환자예후교호.
Objective To investigate the expression of fragile histidine triad(FHIT),fibronectin (FN) and phosphatase and tensin homology deleted on chromosome ten( PTEN )in human hepatocellular carcinomas (HCC) and their relationship with pathological characteristics and prognosis of HCC.Methods Immunohistochemistry was used to detect expression of FHIT,FN and PTEN in cancerous tissues from 138 HCC patients.The correlation between their expression and clinicpathological features and prognosis were analyzed.Results FHIT,FN,PTEN protein expressed differently between HCC and adjacent mucosa ( respectively x2 =5.968,7.380,4.962,all P ＜ 0.05 ),and the expression level was different with tumor size,tumor number,grades and tumor lymph node metastasis( P ＜ 0.05 ).In FHIT and FN positive group,the recurrence free survival rates were lower than those in negative groups( respectively x2 =4.443,9.867,all P ＜0.05),while in PTEN positive group patients' recurrence free survival rates were higher than those with PTEN negative expression ( x2 =4.199,P ＜ 0.05 ).Conclusions FHIT,FN,PTEN were abnormally expressed in HCC.Positive expression of FHIT and FN predicts poor prognosis,while positive PTEN indicates fair prognosis.