CAJ | 학술논문

目的　研究铜针电栓塞血管的机制，为临床治疗提供参考依据。方法　以体外实验和大鼠体内实验为模型，用电子物理学、原子光谱吸收法、组织学和组织化学等方法研究铜针通电后血栓形成的机制和条件。结果　铜针通电后有大量铜离子解离及红细胞聚集，在一定电压和通电时间作用下血管内形成稳定的血栓。结论铜离子解离和红细胞聚集是铜针电栓塞血管的主要机制，稳压直流电4 V和17.5分钟的通电时间为血栓形成的安全有效条件。
목적　연구동침전전새혈관적궤제，위림상치료제공삼고의거。방법　이체외실험화대서체내실험위모형，용전자물이학、원자광보흡수법、조직학화조직화학등방법연구동침통전후혈전형성적궤제화조건。결과　동침통전후유대량동리자해리급홍세포취집，재일정전압화통전시간작용하혈관내형성은정적혈전。결론동리자해리화홍세포취집시동침전전새혈관적주요궤제，은압직류전4 V화17.5분종적통전시간위혈전형성적안전유효조건。
Objective　To investigate the mechanism of electrothrombosis by copper needle, in order to supply the referential data for clinical treatment of vessel deformity. Methods　The mechanism and condition of thrombus formation by copper needle were studied in vivo and in vitro using electrophysics, atom absorption spectrophtometry, histological, and histochemical methods. Results　Great deal of copper ion was dissociated, and agglutination of red blood cells(RBC) in blood could be observed in vitro after the current applied by copper needles. Formation of stable thrombus was related to voltage and time of application of electric current. Conclusion　Dissociation of copper ion and agglutination of RBC are the basic principle of electrothrombosis with copper needle. A 4V direct current and 17.5 minutes are the safe and effective conditions for thrombus formation in the blood vessels.