CAJ | 학술논문

目的:研究大气可吸入颗粒物PM10(particulate matter of aerodynamic diameter ＜10 μm)和细颗粒物PM2.5(particulate matter of aerodynamic diameter＜2.5 μm)对健康学龄儿童肺功能的短期影响.方法:于2008年10月选取北京市两所小学的216名7～11岁小学生为研究对象,统一测量其反映呼吸道大气道功能和小气道功能的8项肺功能指标,同时监测肺功能测量当天及前4天校园中PM2.5的水平及温度和相对湿度,并同时收集由北京市环保局公布的学校附近监测站的PM10的浓度数据;采用岭回归分析PM10和PM2.5对肺功能的短期影响.结果:在累计滞后1 d(Lag0-1)和2 d(Lag0-2)时,随着PM10和PM2.5浓度的增加,反映大气道功能的缓慢肺活量(slow vital capacity,SVC)、用力肺活量(forced vital capacity,FVC)和第一秒用力肺活量(forced expiratory volume in one second,FEV1.0)以及反映小气道功能的最大呼气中段流速(forced expiratory flow between 25%and 75% of vital capacity,FEF25-75)、75%用力肺活量时的呼气流速(forced expiratory flow after 25% of vital capacity has been expelled,FEF25)和50%用力肺活量时的呼气流速(forced expiratory flow after 50% of vital capacity has been expelled,FEF50)有不同程度的下降,但以大气道功能指标下降更为明显,且女生的SVC、FVC和FEV1.0的下降程度略大于男生.结论:大气PM10和PM2.5对儿童肺功能存在短期负效应,并存在一定滞后性,且在反映大气道功能的指标FVC和FEV1.0上表现得更为明显;女生的大气道功能对于颗粒物的不良影响更为敏感.
목적:연구대기가흡입과립물PM10(particulate matter of aerodynamic diameter ＜10 μm)화세과립물PM2.5(particulate matter of aerodynamic diameter＜2.5 μm)대건강학령인동폐공능적단기영향.방법:우2008년10월선취북경시량소소학적216명7～11세소학생위연구대상,통일측량기반영호흡도대기도공능화소기도공능적8항폐공능지표,동시감측폐공능측량당천급전4천교완중PM2.5적수평급온도화상대습도,병동시수집유북경시배보국공포적학교부근감측참적PM10적농도수거;채용령회귀분석PM10화PM2.5대폐공능적단기영향.결과:재루계체후1 d(Lag0-1)화2 d(Lag0-2)시,수착PM10화PM2.5농도적증가,반영대기도공능적완만폐활량(slow vital capacity,SVC)、용력폐활량(forced vital capacity,FVC)화제일초용력폐활량(forced expiratory volume in one second,FEV1.0)이급반영소기도공능적최대호기중단류속(forced expiratory flow between 25%and 75% of vital capacity,FEF25-75)、75%용력폐활량시적호기류속(forced expiratory flow after 25% of vital capacity has been expelled,FEF25)화50%용력폐활량시적호기류속(forced expiratory flow after 50% of vital capacity has been expelled,FEF50)유불동정도적하강,단이대기도공능지표하강경위명현,차녀생적SVC、FVC화FEV1.0적하강정도략대우남생.결론:대기PM10화PM2.5대인동폐공능존재단기부효응,병존재일정체후성,차재반영대기도공능적지표FVC화FEV1.0상표현득경위명현;녀생적대기도공능대우과립물적불량영향경위민감.