中国医药
中國醫藥
중국의약
CHINA MEDICINE
2011年
11期
1391-1392
,共2页
于巨哲%于云雷%谭玉成%王江
于巨哲%于雲雷%譚玉成%王江
우거철%우운뢰%담옥성%왕강
乳腺肿瘤%注射用血凝酶%止血
乳腺腫瘤%註射用血凝酶%止血
유선종류%주사용혈응매%지혈
Breast Neoplasms%Injection reptilase%Hemostasis
目的 观察注射用血凝酶在改良乳腺癌根治术中及术后的止血效果.方法 将80例行改良乳腺癌根治术的乳腺癌患者完全随机分成血凝酶组和对照组,各40例.血凝酶组于术前1小时肌内注射血凝酶1U,术前15 min静注1U,术后2d每天肌内注射1U；对照组采用0.9％氯化钠注射液浸泡纱布.记录、观察并对比2组创面止血时间、单位面积渗血量、术中出血量(记录吸引器液体量及纱布差值)、术后2d的引流量及凝血功能.结果 血凝酶组切口止血时间、切口单位面积渗血量、术中出血量、术后2d的引流量均明显少于对照组[止血时间:(102.3 ±24.2)s比(118.8±30.1)s;切口单位面积渗血量:(0.3 ±0.1)g/cm2比(0.4±0.2) g/cm2；术中出血量:(14.2±3.6)g比(20.9±5.1)g；术后2d引流量:(4.5±0.4)ml比(8.2±0.6)ml],差异均有统计学意义(均P＜0.05).而2组术前和术后24h凝血功能差异无统计学意义(P＞0.05).结论 注射用血凝酶在改良乳腺癌根治术中的止血效果明显,能减少术中、术后出血,缩短手术时间,且对凝血功能影响不大.
目的 觀察註射用血凝酶在改良乳腺癌根治術中及術後的止血效果.方法 將80例行改良乳腺癌根治術的乳腺癌患者完全隨機分成血凝酶組和對照組,各40例.血凝酶組于術前1小時肌內註射血凝酶1U,術前15 min靜註1U,術後2d每天肌內註射1U；對照組採用0.9％氯化鈉註射液浸泡紗佈.記錄、觀察併對比2組創麵止血時間、單位麵積滲血量、術中齣血量(記錄吸引器液體量及紗佈差值)、術後2d的引流量及凝血功能.結果 血凝酶組切口止血時間、切口單位麵積滲血量、術中齣血量、術後2d的引流量均明顯少于對照組[止血時間:(102.3 ±24.2)s比(118.8±30.1)s;切口單位麵積滲血量:(0.3 ±0.1)g/cm2比(0.4±0.2) g/cm2；術中齣血量:(14.2±3.6)g比(20.9±5.1)g；術後2d引流量:(4.5±0.4)ml比(8.2±0.6)ml],差異均有統計學意義(均P＜0.05).而2組術前和術後24h凝血功能差異無統計學意義(P＞0.05).結論 註射用血凝酶在改良乳腺癌根治術中的止血效果明顯,能減少術中、術後齣血,縮短手術時間,且對凝血功能影響不大.
목적 관찰주사용혈응매재개량유선암근치술중급술후적지혈효과.방법 장80례행개량유선암근치술적유선암환자완전수궤분성혈응매조화대조조,각40례.혈응매조우술전1소시기내주사혈응매1U,술전15 min정주1U,술후2d매천기내주사1U；대조조채용0.9％록화납주사액침포사포.기록、관찰병대비2조창면지혈시간、단위면적삼혈량、술중출혈량(기록흡인기액체량급사포차치)、술후2d적인류량급응혈공능.결과 혈응매조절구지혈시간、절구단위면적삼혈량、술중출혈량、술후2d적인류량균명현소우대조조[지혈시간:(102.3 ±24.2)s비(118.8±30.1)s;절구단위면적삼혈량:(0.3 ±0.1)g/cm2비(0.4±0.2) g/cm2；술중출혈량:(14.2±3.6)g비(20.9±5.1)g；술후2d인류량:(4.5±0.4)ml비(8.2±0.6)ml],차이균유통계학의의(균P＜0.05).이2조술전화술후24h응혈공능차이무통계학의의(P＞0.05).결론 주사용혈응매재개량유선암근치술중적지혈효과명현,능감소술중、술후출혈,축단수술시간,차대응혈공능영향불대.
Objective To observe the Hemocoagulase Atrox's hemostasis effect during and after modified radical mastectomy.Methods Eighty breast cancer patients undergoing the modified radical mastectomy were divided into two groups and each group included 40 cases.Hemostasis time,wound's bleeding volume per centimeter,bleeding volume during the operation,drainage 2days after operation and it's effect on Blood coagulation function (PT,APTT,PLT,Fib) were observed.Results The hemostasis time,wound's bleeding volume per centimeter,bleeding volume during the operation and drainage 2days after operation in the Hemocoagulase Atrox group were shorter than those of the control group significantly.And at the same time,the blood coagulation function 24 hours before and after operation of two groups were not different significantly ( P ＞ 0.05 ).Conclusions The hemostasis function of Hemocoagulase Atrox for Injection in modified radical mastectomy is significant.It can reduce the bleeding volume during and after the operation,shorten the operation time.But it's effect on blood coagulation function is linited.
