CAJ | 학술논문

目的探讨高强度聚焦超声(high intensity focused ultrasound,HIFU)消融治疗胰腺癌的疗效和安全性.方法采用JC型高强度聚焦超声治疗系统,消融治疗44例胰腺癌患者.观察治疗前后的影像学变化及临床症状,评价HIFU治疗的疼痛缓解程度、生存期及不良反应.结果44例患者经HIFU治疗后,疼痛缓解率为94.74%,1、3、5年生存率分别为15.91%、6.82%、2.27%,中位生存时间为8个月(3～71个月).无上消化道出血或胃肠穿孔等严重并发症.增强CT或MRI显示HIFU治疗区内组织消融.结论HIFU是一种治疗胰腺癌的有效方法.该法无创、安全性较高、止痛效果明显,适合病情较重、不能耐受其他方法治疗的患者.
목적탐토고강도취초초성(high intensity focused ultrasound,HIFU)소융치료이선암적료효화안전성.방법채용JC형고강도취초초성치료계통,소융치료44례이선암환자.관찰치료전후적영상학변화급림상증상,평개HIFU치료적동통완해정도、생존기급불량반응.결과44례환자경HIFU치료후,동통완해솔위94.74%,1、3、5년생존솔분별위15.91%、6.82%、2.27%,중위생존시간위8개월(3～71개월).무상소화도출혈혹위장천공등엄중병발증.증강CT혹MRI현시HIFU치료구내조직소융.결론HIFU시일충치료이선암적유효방법.해법무창、안전성교고、지통효과명현,괄합병정교중、불능내수기타방법치료적환자.
Objective To explore the efficacy and safety of high intensity focused ultrasound (HIFU) on pancreatic carcinoma. Methods Forty-four patients with pancreatic carcinoma were treated with HIFU. The response rate, clinical beneficial response, overall survival and side effects were evaluated after the treatment. Results The rate of pain relief was 94.74%, the overall 1-, 3-, and 5-years survival rates were 15.91 %, 6. 82%, 2. 27%, respectively;and the median survival time was 8(3～71) months. No complications, such as pancreatisis and gastrointestinal injury occurred. Conclusion HIFU is an effective, non invasive and safe approach in the treatment of pancreatic carcinoma.For the patients with severe condition and intolerable to other methods, HIFU may be a good choice.