CAJ | 학술논문

目的探讨未用药的精神分裂症患者病程与其糖脂代谢指标的关系. 方法选择自2010年3月至2011年10月在中山大学附属第三医院精神科住院的且未用药的186例精神分裂症患者为研究对象,测定各例患者的糖脂代谢相关指标并评估阳性和阴性症状量表(PANSS),采用多元回归分析检验自变量病程和各控制变量(年龄、性别、文化程度、疾病严重程度)与糖脂代谢指标间的关系. 结果控制变量中性别对多个糖脂代谢指标的影响较显著(腰臀比:β=0.364,高密度脂蛋白:β=-0.248,三酰甘油:β=0.167,脂蛋白:β=-0.198),差异有统计学意义(P＜0.05)；年龄亦对多个糖脂代谢指标的影响较显著(体质量指数:β=0.213,腰臀比:β=0.286,载脂蛋白B100:β=0.221),差异有统计学意义(P＜0.05)；疾病严重程度也影响着一些糖脂代谢指标(体质量指数:β=-0.167,腰臀比:β=-0.150,空腹血糖:β=0.172),差异有统计学意义(P＜0.05).但在严格控制年龄、性别、文化程度和疾病严重度等控制变量影响的情况下,回归分析发现:作为自变量的病程仅仅影响到患者的脂蛋白(β=0.173).对其它糖脂代谢指标则无统计学意义的影响. 结论精神分裂症患者的高代谢异常发生率不能单一用遗传素质来解释,可能是多因素交互作用的结果.
목적 탐토미용약적정신분렬증환자병정여기당지대사지표적관계. 방법 선택자2010년3월지2011년10월재중산대학부속제삼의원정신과주원적차미용약적186례정신분렬증환자위연구대상,측정각례환자적당지대사상관지표병평고양성화음성증상량표(PANSS),채용다원회귀분석검험자변량병정화각공제변량(년령、성별、문화정도、질병엄중정도)여당지대사지표간적관계. 결과 공제변량중성별대다개당지대사지표적영향교현저(요둔비:β=0.364,고밀도지단백:β=-0.248,삼선감유:β=0.167,지단백:β=-0.198),차이유통계학의의(P＜0.05)；년령역대다개당지대사지표적영향교현저(체질량지수:β=0.213,요둔비:β=0.286,재지단백B100:β=0.221),차이유통계학의의(P＜0.05)；질병엄중정도야영향착일사당지대사지표(체질량지수:β=-0.167,요둔비:β=-0.150,공복혈당:β=0.172),차이유통계학의의(P＜0.05).단재엄격공제년령、성별、문화정도화질병엄중도등공제변량영향적정황하,회귀분석발현:작위자변량적병정부부영향도환자적지단백(β=0.173).대기타당지대사지표칙무통계학의의적영향. 결론 정신분렬증환자적고대사이상발생솔불능단일용유전소질래해석,가능시다인소교호작용적결과.
Objective To explore the relationship between the course of disease and glycolipid metabolic parameters in drug-naive schizophrenia patients. Methods All 186 drug-naive schizophrenia patients,admired to our hospital from March 2010 to October 2011,were chosen in our study; relative glycolipid metabolic parameters at baseline were tested and Positive and Negative Syndrome Scale (PANSS) was performed on these patients; and the relationships between relative glycolipid metabolic indexes and both the course of disease and manipulated variable (age,gender,education level and severity of the disease) were assessed.Results Gender might play a significant role to some glycolipid metabolic parameters (waist-hip ratio [WHR]:β=0.364; high-density lipoprotein [HDL]:β=-0.248; triacyiglycerol [TG]:β=0.167 and lysophosphatidic acid (LPA):β=-0.198,P＜0.05); age might play an important role to some glycolipid metabolic parameters (body mass index [BMI]: β=0.213; WHR: β=0.286 and apolipoprotein B 100 [apoB100]:β=0.221,P＜0.05).Simultaneously,the severity of disease appeared to affect some glycolipid metabolic parameters (BMI:β-0.167; WHR:β=-0.150 and fasting blood-glucose [FBG]:β=0.172, P＜0.05). The course of disease hardly affected the majorities of relative glycolipid metabolic indices of drug-naive schizophrenia but LPa (β=0.173, P＜0.05). Conclusion The high metabolic abnormality incidence in schizophrenia patients maybe result from multi-factor interactions.