中国医药
中國醫藥
중국의약
CHINA MEDICINE
2012年
4期
406-408
,共3页
孙东燕%姜雪丽%马天瑞%赵兴美%冯平
孫東燕%薑雪麗%馬天瑞%趙興美%馮平
손동연%강설려%마천서%조흥미%풍평
妇产科手术%氟哌利多%术后硬膜外自控镇痛%锥体外系反应
婦產科手術%氟哌利多%術後硬膜外自控鎮痛%錐體外繫反應
부산과수술%불고리다%술후경막외자공진통%추체외계반응
Gynecologic and obstetric surgery%Droperidol%Postoperative epidural analgesia%Extrapyramidal reactions
目的 观察氟哌利多对不同妇产科手术术后镇痛锥体外系反应的影响,提高临床用药的安全性.方法 回顾性分析3568例我院妇产科术后硬膜外镇痛患者的临床资料.2007年1月至2008年6月妇产科术后硬膜外自控镇痛患者1816例:宫外孕手术176例,剖宫产992例,子宫切除术392例,其他妇产科手术256例,100 ml镇痛液中加入氟哌利多5.0 mg;2008年7月至2009年6月,妇产科术后硬膜外自控镇痛患者1752例:宫外孕手术163例,剖宫产973例,子宫切除术357例,其他妇产科手术259例,100ml镇痛液中加入氟哌利多2.5 mg.结果 使用5.0 mg氟哌利多术后镇痛妇产科患者1816例,发生锥体外系反应13例,发生率为0.72％；使用2.5 mg氟哌利多术后镇痛妇产科患者1752例,无一例锥体外系反应发生,2组患者锥体外系反应发生率差异有统计学意义(x2=12.59,P＜0.01).使用5.0 mg氟哌利多术后镇痛妇产科患者中宫外孕手术、剖宫产、子宫切除术患者锥体外系反应发生率分别为4.55％(8/176)、0.30％(3/992)、0,3种不同术式锥体外系反应发生率差异有统计学意义(x2=28.85,P＜0.01).结论 氟哌利多术后硬膜外镇痛引起锥体外系反应与用药剂量、年龄等因素有关.
目的 觀察氟哌利多對不同婦產科手術術後鎮痛錐體外繫反應的影響,提高臨床用藥的安全性.方法 迴顧性分析3568例我院婦產科術後硬膜外鎮痛患者的臨床資料.2007年1月至2008年6月婦產科術後硬膜外自控鎮痛患者1816例:宮外孕手術176例,剖宮產992例,子宮切除術392例,其他婦產科手術256例,100 ml鎮痛液中加入氟哌利多5.0 mg;2008年7月至2009年6月,婦產科術後硬膜外自控鎮痛患者1752例:宮外孕手術163例,剖宮產973例,子宮切除術357例,其他婦產科手術259例,100ml鎮痛液中加入氟哌利多2.5 mg.結果 使用5.0 mg氟哌利多術後鎮痛婦產科患者1816例,髮生錐體外繫反應13例,髮生率為0.72％；使用2.5 mg氟哌利多術後鎮痛婦產科患者1752例,無一例錐體外繫反應髮生,2組患者錐體外繫反應髮生率差異有統計學意義(x2=12.59,P＜0.01).使用5.0 mg氟哌利多術後鎮痛婦產科患者中宮外孕手術、剖宮產、子宮切除術患者錐體外繫反應髮生率分彆為4.55％(8/176)、0.30％(3/992)、0,3種不同術式錐體外繫反應髮生率差異有統計學意義(x2=28.85,P＜0.01).結論 氟哌利多術後硬膜外鎮痛引起錐體外繫反應與用藥劑量、年齡等因素有關.
목적 관찰불고리다대불동부산과수술술후진통추체외계반응적영향,제고림상용약적안전성.방법 회고성분석3568례아원부산과술후경막외진통환자적림상자료.2007년1월지2008년6월부산과술후경막외자공진통환자1816례:궁외잉수술176례,부궁산992례,자궁절제술392례,기타부산과수술256례,100 ml진통액중가입불고리다5.0 mg;2008년7월지2009년6월,부산과술후경막외자공진통환자1752례:궁외잉수술163례,부궁산973례,자궁절제술357례,기타부산과수술259례,100ml진통액중가입불고리다2.5 mg.결과 사용5.0 mg불고리다술후진통부산과환자1816례,발생추체외계반응13례,발생솔위0.72％；사용2.5 mg불고리다술후진통부산과환자1752례,무일례추체외계반응발생,2조환자추체외계반응발생솔차이유통계학의의(x2=12.59,P＜0.01).사용5.0 mg불고리다술후진통부산과환자중궁외잉수술、부궁산、자궁절제술환자추체외계반응발생솔분별위4.55％(8/176)、0.30％(3/992)、0,3충불동술식추체외계반응발생솔차이유통계학의의(x2=28.85,P＜0.01).결론 불고리다술후경막외진통인기추체외계반응여용약제량、년령등인소유관.
Objective To observe the effects of droperidol on postoperative analgesia extrapyramidal reactions in different gynecologic and obstetric surgery,and the safety of clinical drug.Methods Clinical data from 3568 patients of epidural analgesia after gynecologic and obstetric surgery were analyzed.There were 176 cases with ectopic pregnancy surgery,992 cases with cesarean section,392 cases with hysterectomy,256 cases with other gynecologic and obstetric surgery in 1816 cases with postoperative epidural analgesia from June 2007 to June 2008.5mg droperidol were added into 100 ml analgesic solution for treatment.From July 2008 to June 2009,in 1752 patients of epidural analgesia after gynecologic and obstetric surgery,there were 163 cases with ectopic pregnancy surgery,973 cases with cesarean section,357 cases with hysterectomy and 259 cases with other gynecologic and obstetric surgery.In these cases,2.5 mg droperidol were added into 100 ml analgesic solution.Results In 1816 patients treated with 5 mg droperidol,extrapyramidal reactions occurred in 13 cases.The incidence was 0.72％.In 1752 patients treated with 2.5 mg droperidol,no extrapyramidal reactions occurred.There was a significant statistical difference in the incidences of extrapyramidal reactions between the two groups of patients (x2 =12.59,P ＜0.01 ).Among the patients treated with 5 mg droperidol,the incidences of extrapyramidal reactions after the surgery of ectopic pregnancy,cesarean section and hysterectomy were 4.55％,0.30％ and 0％.There were significant differences of the three different surgical procedures (x2 =28.85,P ＜ 0.01 ).Conclusion Extrapyramidal reactions of droperidol in postoperative epidural analgesia are associated with dose,age,medication methods,compatibility and perioperative mental state of patients.
