CAJ | 학술논문

目的评估α1肾上腺能受体阻滞剂联用前列腺素合成酶抑制剂治疗下段输尿管结石的效果.方法 94例下段输尿管结石患者随机为实验组和对照组.实验组予以坦索罗辛0.2 mg 口服,1次/d,双氯芬酸钠栓50 mg肛塞,2次/d;对照组未用药物,等待结石自排.以结石排出输尿管或治疗随访2周为疗效观察终点.结果实验组和对照组无患者退出研究.实验组排石率[91.5%(43/47)]高于对照组[25.5%(12/47)](P＜0.01);实验组结石排出时间[(6.4±3.7)d]短于对照组[(8.9±4.3)d](P＜0.01);实验组再发肾输尿管绞痛率[4.3%(2/47)]少于对照组[48.9%(23/47)](P＜0.01).结论坦索罗辛联用双氯芬酸钠栓治疗下段输尿管结石可以缩短结石排出时间,减少并发症,提高排石率.
목적 평고α1신상선능수체조체제련용전렬선소합성매억제제치료하단수뇨관결석적효과.방법 94례하단수뇨관결석환자수궤위실험조화대조조.실험조여이탄색라신0.2 mg 구복,1차/d,쌍록분산납전50 mg항새,2차/d;대조조미용약물,등대결석자배.이결석배출수뇨관혹치료수방2주위료효관찰종점.결과 실험조화대조조무환자퇴출연구.실험조배석솔[91.5%(43/47)]고우대조조[25.5%(12/47)](P＜0.01);실험조결석배출시간[(6.4±3.7)d]단우대조조[(8.9±4.3)d](P＜0.01);실험조재발신수뇨관교통솔[4.3%(2/47)]소우대조조[48.9%(23/47)](P＜0.01).결론 탄색라신련용쌍록분산납전치료하단수뇨관결석가이축단결석배출시간,감소병발증,제고배석솔.
Objective To evaluate the clinical efficacy of expulsive therapy using alpha 1-selective adrenoblocker and prostaglandin synthetase inhibitor for distal ureteral stones.Methods 94 patients with distal ureteral stone were randomly divided into study group and control group.In study group,47 cases received tamsulosin 0.2mg daily and dielofenac rectal suppositories 50mg 2 times daily,while watchful waiting without tamsulosin and diclofenac suppository in 47 cases of control group.Observation lasted 2 weeks and also stone expelled as end point.Results No severe adverse reactions related to the drugs were noted and no patients withdrew from the study.The stone-free rate was 91.5%(43/47) of the study group and 25.5% (12/47) of the control group (P＜0.01).A mean stone expelling date of the control group was(8.9±4.3)d and that of the study group was(6.4±3.7)d(P＜0.01).Rates of renoureteral colic recurred in the study group and the control group were 4.3%(2/47) and 48.9%(23/47),respectively (P＜0.01).Conclusion Treatment of distal ureteral stones wlth tamsulosin and dielofenac suppository can increase the stone-free rate,shorten mean stone expelling date,decrease rate of renottreteral colic recurred.