CAJ | 학술논문

病毒性肝炎临床常用的几种药物(丹参、桃仁、川芎嗪、茵陈、毛冬青、赤芍、甘草甜素,Cynarin和联苯双酯)对大白鼠进行实验.药物经脾动脉入肝动脉进行对比研究.通过激光多普勒血流量仪及胆汁流量仪分别观察其肝脏表面微循环及其胆汁流晕的影响,用药韵大白鼠以盐水作对照,对照值做为:100%.根据用药前后肝脏表面微血管内流量的变化,结果提示:丹参、桃仁、川芎嗪、茵陈等药物有短期增快肝脏局部微循环血流量;毛冬青、赤芍主要加速胆汁分泌的作用;而甘草甜索、联苯双酯和Cynarin既无加快局部微循环,又无增加胆汁分泌的作用.
병독성간염림상상용적궤충약물(단삼、도인、천궁진、인진、모동청、적작、감초첨소,Cynarin화련분쌍지)대대백서진행실험.약물경비동맥입간동맥진행대비연구.통과격광다보륵혈류량의급담즙류량의분별관찰기간장표면미순배급기담즙류훈적영향,용약운대백서이염수작대조,대조치주위:100%.근거용약전후간장표면미혈관내류량적변화,결과제시:단삼、도인、천궁진、인진등약물유단기증쾌간장국부미순배혈류량;모동청、적작주요가속담즙분비적작용;이감초첨색、련분쌍지화Cynarin기무가쾌국부미순배,우무증가담즙분비적작용.
Nine drugs(Salvia Miltiornhiza Prunus kernal,Teramethyl pyrazine,Artenisia capilladis thumb llex pubesoens,Catechin,Cynarin,jGlyoerrhizin and Fruotus Schizandrae)commonly used for treating viral hepatitis were applied to rats.Blood flow on the liver surface was monitered by a laser-Doppler flowmetar.The control flow value was taken as 100%.Bile secretion rate(ul.min)was measured with a drop counted from a cannola in the common bile duct.Dose-response ourves were produced by infusion drugs into the hepatio artery via a cannula in the ligated splenic artery.The results showed that hepatic blood flow was increased by the Prunus kernel,Teramethyl pyrazine and Artemisia capillaris thumb.Bile seoretion was accelerated by the Ilex pubescens and Cateohin.Glycyrrhizin,Cynarin and Fructus Schixendrae had neither action on the hepatic microciroulation nor the bile secretion.