CAJ | 학술논문

采用Lavorell氏火箭电泳法和改良Lane氏法分别对24名正常人和各型病毒性肝炎患者135例进行了血清前白蛋白(PA):转铁蛋白(Tf)和抗胰蛋白酶(а1-AT)检测.有45%的患者血清自蛋白正常而PA降低,其中3例PA降至零者均治疗无效死亡.各型肝炎的Tf含量均显著低于正常对照组,其下降程度依次为重型肝炎,肝硬化,慢性活动性肝炎、慢性迁延性肝炎和急性肝炎.血清а1-AT除急性肝炎时增高和重型肝炎降低外,其它各型肝炎均无明显变化.肝病时综合分析此三种蛋白的变化对肝炎的诊断,治疗和预后判断均有一定的临床意义.
채용Lavorell씨화전전영법화개량Lane씨법분별대24명정상인화각형병독성간염환자135례진행료혈청전백단백(PA):전철단백(Tf)화항이단백매(а1-AT)검측.유45%적환자혈청자단백정상이PA강저,기중3례PA강지령자균치료무효사망.각형간염적Tf함량균현저저우정상대조조,기하강정도의차위중형간염,간경화,만성활동성간염、만성천연성간염화급성간염.혈청а1-AT제급성간염시증고화중형간염강저외,기타각형간염균무명현변화.간병시종합분석차삼충단백적변화대간염적진단,치료화예후판단균유일정적림상의의.
Serum prealbumin(PA),transferrin (Tf) and α1-antitrypsin (α1-AT) were measured in 135 cases with different types of viral hepatitis and in 24 normal subjects by using Lanrell technique (rocket electrophoresis) and modified Lane technique respectively.Among them,serum PA levels were decreased (normal limit 32.54±6.18mg/dl)in 45%of the patients,3 of them died while their serum PA levels decreased to zero.However.their serum albumin still remained in normal range.Serum Tf levels in viral hepatitis were significantly lower than in normal control (253.87±52.21 mg/dl) and the degree of decrease of serum Tf was listed below:severe hepatitis＞liver cirrhosis＞chronic active hepatitis＞chronic persistent hepatitis＞acute hepatitis.The changes of serum α1-AT in viral hepatitis showed no significant difference,except its level increased in acute hepatitis and decreased in severe hepatitis.Therefore,the measurement of serum PA,Tf and α1-AT may be helpful in estimation of the diagnosis,treatment ad prognosis of liver disease.