CAJ | 학술논문

目的探讨蒙古族原发性高血压患者血尿酸水平与早期肾损害的关系和可能机制.方法选择蒙古族高血压患者86例,汉族高血压患者89例,分别采用尿素酶法测定血尿酸(UA)免疫比浊法测定胱抑素C(Cys-C)、β2微球蛋白(β2m),进行比较分析.结果蒙古族高血压组UA(456.32±45.49)μmol/L显著高于汉族高血压组(456.32±45.49)比UA(385.30±37.85)μmol/L(P＜0.05).蒙古族组及汉族组UA与Cys-C、β2m均呈正相关(r=0.714、0.694;r=0.624、0.526;P＜0.05),在Ccr＜50m1/min时,Ccr与UA(r=0.72)、Cys-C(r=0.68)、β2m(r=0.75),SCr(r=0.65)均有较好相关性呈正相关,r分别为0.72、0.68、0.75、0.65.Ccr为50～80 ml/min时,Ccr与UA、Cys-C、β2 m的相关性,r分别为0.75、0.73、0.70,而Ccr与SCr的r值为0.55.结论蒙古族高血压人群高尿酸血症患者更容易出现肾损害.
목적 탐토몽고족원발성고혈압환자혈뇨산수평여조기신손해적관계화가능궤제.방법 선택몽고족고혈압환자86례,한족고혈압환자89례,분별채용뇨소매법측정혈뇨산(UA)면역비탁법측정광억소C(Cys-C)、β2미구단백(β2m),진행비교분석.결과 몽고족고혈압조UA(456.32±45.49)μmol/L현저고우한족고혈압조(456.32±45.49)비UA(385.30±37.85)μmol/L(P＜0.05).몽고족조급한족조UA여Cys-C、β2m균정정상관(r=0.714、0.694;r=0.624、0.526;P＜0.05),재Ccr＜50m1/min시,Ccr여UA(r=0.72)、Cys-C(r=0.68)、β2m(r=0.75),SCr(r=0.65)균유교호상관성정정상관,r분별위0.72、0.68、0.75、0.65.Ccr위50～80 ml/min시,Ccr여UA、Cys-C、β2 m적상관성,r분별위0.75、0.73、0.70,이Ccr여SCr적r치위0.55.결론 몽고족고혈압인군고뇨산혈증환자경용역출현신손해.
Objective To discuss the relationship and possible mechanism between serum uric acid level and renal injury in early stage in Monglian patients with essential hypertension.Methods The patients with high blood pressure were chosen as the subjets,which the Mongolian patients were 86 cases and Han 89 cases.They were separately detected UA in the method of urease and Cys-C,β2 m in the way ofturbidimetric immunoassay.The data concerned were compared with each other.Results In Mongolian patients group with highblood pressure,the rate of uric acid was (456.32 ±45.49) μmol/L;that of Han patients group was (385.30 ±37.85) μmol/L.The rate of uric acid between Mongolian group and Han group showed apparent difference(P ＜0.05).UA showed positive correlation with Cys-c (r = 0.714、0.694,P ＜ 0.05)while U A showed positive correlation with β2 m(r =0.624、0.526,P ＜0.05)in the Mongolian group and in the Han group.CCr showed correlation with UA、Cys-c、β2 m when CCr ＜ 50 ml/min,r was 0.72、0.68、0.75、0.65 respectively;CCr showed correlation with UA、Cys-c、β2 m when CCr was 50-80 mL/min,r was 0.75,0.73,0.70.CCr showed correalation with SCr,r was 0.55.Conclusion Those Mongolian patients with hypertension were more likely to show the symptoms of renal injury and metabolic disorder.