CAJ | 학술논문

术后认知功能障碍(POCD)的病因复杂,在老年患者中较多见,但其机制尚未明确.全麻药在POCD发生中的作用及其机制已有许多研究,结果复杂而多样.另外,有一些动物或离体研究表明全麻药可促发阿尔茨海默病(AD)的发病过程并可能因此促发AD的发病和导致POCD.因此,研究全麻药在POCD和术后AD发病中的作用,特别是探求其中可能存在的共同机制是有意义的.
술후인지공능장애(POCD)적병인복잡,재노년환자중교다견,단기궤제상미명학.전마약재POCD발생중적작용급기궤제이유허다연구,결과복잡이다양.령외,유일사동물혹리체연구표명전마약가촉발아이자해묵병(AD)적발병과정병가능인차촉발AD적발병화도치POCD.인차,연구전마약재POCD화술후AD발병중적작용,특별시탐구기중가능존재적공동궤제시유의의적.
Postoperative lognitive dystunction (POCD) may occur in postoperative period. However, the molecular mechanisms underlying POCD is tmknown. Although many studies in association of anesthetics and POCD have been conducted, the results are muhiplicate. Some recent studies in vitro reported that anesthetics may activate neuropathogenesis of Alzheimer's disease (AD) and supposed that anesthetics may cause POCD or AD.