CAJ | 학술논문

氯胺酮是NMDA受体的非竞争性拮抗剂.研究显示,它能够损伤工作记忆、情节记忆和语义记忆并且伴随着精神症状和分离幻觉的出现,揭示其对认知功能有影响.它可能通过NMDA受体、烟碱受体、GABA和GABA受体、钠通道干扰长时程增强(long-term potentiation,LTP)的功能,从而影响认知功能.
록알동시NMDA수체적비경쟁성길항제.연구현시,타능구손상공작기억、정절기억화어의기억병차반수착정신증상화분리환각적출현,게시기대인지공능유영향.타가능통과NMDA수체、연감수체、GABA화GABA수체、납통도간우장시정증강(long-term potentiation,LTP)적공능,종이영향인지공능.
Ketamine is a non-competitive antagonist of N-methy-D-Asparte(NMDA) glutamatergic receptor. Available researches suggest it produces impairments of working, episodic and semantic memory along with psychotogenic and dissociative effects, which shows that it impairs cognitive function. It interferes with the function of long-term potentiation (LTP) through NMDA receptor, Nicotinic receptor, GABA and GABA receptor, sodium channel.