CAJ | 학술논문

背景水通道蛋白(aquaporin,AQP)是一类高效率跨膜转运水分子的蛋白通道家族,参与诸多组织器官中的水转运及细胞内外的水平衡.现已证实有6种AQP(AQP1、3、4、5、8、9)分布于肺组织,有大量研究证明AQP1、5在肺水转运中的作用尤为重要.目的通过对AQP1、5在急性肺损伤(acute lung injury,ALI)中的作用的研究来指导临床实践.内容探讨AQP1、5在ALI中的作用及调控机制.趋势随着对AQP1、5作用机制研究的不断深入,给相关疾病的防治带来了希望.
배경 수통도단백(aquaporin,AQP)시일류고효솔과막전운수분자적단백통도가족,삼여제다조직기관중적수전운급세포내외적수평형.현이증실유6충AQP(AQP1、3、4、5、8、9)분포우폐조직,유대량연구증명AQP1、5재폐수전운중적작용우위중요.목적 통과대AQP1、5재급성폐손상(acute lung injury,ALI)중적작용적연구래지도림상실천.내용 탐토AQP1、5재ALI중적작용급조공궤제.추세 수착대AQP1、5작용궤제연구적불단심입,급상관질병적방치대래료희망.
Background Aquaporins(AQP),a kind of high efficiency family of transmembrane water channels,participate in the water transport of kinds of tissues and organs,and they also maintain intracellular & extracellular water balance.Nowadays,it is showed that there are six aquaporins in the lung tissue,and that AQP1 and AQP5 might play an important role in the water transport of the lung tissue.Objective It is of great clinical significance to clarify the mechanisms of AQP1,5 mediated acute lung injury (ALI).Content This review mainly discusses the lung injury mediated by AQP1,5.Trend With the progresses of the research,it will develop some new clinical prevention and treatment strategys of lung diseases.