CAJ | 학술논문

以不同强度训练大鼠停训28周为对象,应用免疫组织化学技术,探讨运动对大鼠海马神经元细胞凋亡因子Bax、Bcl-2表达的影响.参照Bedford训练方案,建立起Sprague dawley（SD）大鼠有氧训练与疲劳训练动物模型,停训28周后,观察大鼠海马神经元Bax、Bcl-2的表达变化.结果表明：长期有氧训练大鼠老年期海马神经元Bcl-2/Bax比值升高,长期疲劳训练大鼠老年期海马神经元Bcl-2/Bax比值下降.这是因为长期有氧训练促进了大鼠海马神经元产生了良好的适应,对大鼠老年期海马神经元起到保护和延缓其衰老的作用.而长期疲劳训练会影响到大鼠老年期海马神经细胞的功能状态.
이불동강도훈련대서정훈28주위대상,응용면역조직화학기술,탐토운동대대서해마신경원세포조망인자Bax、Bcl-2표체적영향.삼조Bedford훈련방안,건립기Sprague dawley（SD）대서유양훈련여피로훈련동물모형,정훈28주후,관찰대서해마신경원Bax、Bcl-2적표체변화.결과표명：장기유양훈련대서노년기해마신경원Bcl-2/Bax비치승고,장기피로훈련대서노년기해마신경원Bcl-2/Bax비치하강.저시인위장기유양훈련촉진료대서해마신경원산생료량호적괄응,대대서노년기해마신경원기도보호화연완기쇠로적작용.이장기피로훈련회영향도대서노년기해마신경세포적공능상태.
The influence on the expression of Bax、Bcl-2 in the hippocampus neuron of stopping training 28 weeks rats is studied.Refered to the training scheme of Bedford,the training model of SD rats is established.All rats in the normal cage live 28 weeks and the expression change of Bax and Bcl-2 in the Hippocampus Neuron is observed.The results show that aerobic training promotes the ratio of Bcl-2/Bax in CA1 area and CA3 area of hippocampus,fatigue training restrain the ratio of Bcl-2/Bax in CA1 area and CA3 area of hippocampus after stopping training.It is analyzed that aerobic training has taken good care of the hippocampus neuron of the aged rats,fatigue training has effected the function of the hippocampus neuron of the aged rats.