CAJ | 학술논문

目的:综述磷酸钙骨水泥作为药物缓释载体负载不同药物前后的特征性变化,分析药物缓释体系的动力学原理及其影响药物缓释的因素,评述磷酸钙骨水泥药物缓释体系在动物实验和临床研究中的新进展.资料来源:检索人为第一作者,检索文献时限为1985/2009,检索数据库为CNKI数据库(www.cnki.net/index.htm),PubMed数据库(http://www.ncbi.nlm.nih.gov/PubMed).中文检索词为"磷酸钙骨水泥,药物载体,缓释";英文检索词为"Calciumphosphate cement,CPC,Drug delivery system,Release".资料选择:①文章所述内容与磷酸钙骨水泥密切相关.②有关磷酸钙骨水泥作为药物缓释载体的文献.排除重复研究.结局评价指标:磷酸钙骨水泥作为不同药物的缓释载体时其理化性质的变化,药物释放动力学等指标的变化.结果:磷酸钙骨水泥是一种较理想的新型骨骼修复材料.从不同药物对磷酸钙骨水泥理化性质,药物缓释动力学,组织相容性等方面考查显示,它是药物良好的缓释载体.然而,由于磷酸钙骨水泥药物载体体系的抗压强度和黏合性能较差,仅能用于非负重部位骨缺损的修复,限制了它在临床的广泛应用.而此方面的研究目前未取得突破性进展,以后需加强这方面的研究.结论:以磷酸钙骨水泥为载体的药物缓释体系是一种新型的给药方式,植入生物体内骨骼后可以达到修复骨缺损和药物治疗的双重目的,从而配合全身治疗以达到良好的效果.磷酸钙骨水泥药物缓释体系在骨髓炎、骨结核、骨肿瘤、骨折、骨不连和人工关节置换等领域有广阔的应用前景.
목적:종술린산개골수니작위약물완석재체부재불동약물전후적특정성변화,분석약물완석체계적동역학원리급기영향약물완석적인소,평술린산개골수니약물완석체계재동물실험화림상연구중적신진전.자료래원:검색인위제일작자,검색문헌시한위1985/2009,검색수거고위CNKI수거고(www.cnki.net/index.htm),PubMed수거고(http://www.ncbi.nlm.nih.gov/PubMed).중문검색사위"린산개골수니,약물재체,완석";영문검색사위"Calciumphosphate cement,CPC,Drug delivery system,Release".자료선택:①문장소술내용여린산개골수니밀절상관.②유관린산개골수니작위약물완석재체적문헌.배제중복연구.결국평개지표:린산개골수니작위불동약물적완석재체시기이화성질적변화,약물석방동역학등지표적변화.결과:린산개골수니시일충교이상적신형골격수복재료.종불동약물대린산개골수니이화성질,약물완석동역학,조직상용성등방면고사현시,타시약물량호적완석재체.연이,유우린산개골수니약물재체체계적항압강도화점합성능교차,부능용우비부중부위골결손적수복,한제료타재림상적엄범응용.이차방면적연구목전미취득돌파성진전,이후수가강저방면적연구.결론:이린산개골수니위재체적약물완석체계시일충신형적급약방식,식입생물체내골격후가이체도수복골결손화약물치료적쌍중목적,종이배합전신치료이체도량호적효과.린산개골수니약물완석체계재골수염、골결핵、골종류、골절、골불련화인공관절치환등영역유엄활적응용전경.
OBJECTIVE: To review the characteristics changes of calcium phosphate cement (CPC) as drug delayed release carrier before and after carrying different drugs, analyze dynamic principle and influential factors of drug delayed release system, and summarize new advances of CPC in animal experiments and clinical studies.DATA SOURCES: A computer-based online search of CNKI (www.cnki.net/index.htm) and PubMed (http://www.ncbi.nlm.nih.gov/PubMed) was performed for articles published between 1985 and 2009 with the key words of "calcium phosphate cement, CPC, drug delivery system, release" in Chinese and English.DATA SELECTION: Articles highly related with CPC; articles concerning CPC as drug delivery system. Repetitive articles were excluded.MAIN OUTCOME MEASURES: Changes in physico-chemical properties and drug release dynamics of CPC as delivery carrier of different drugs.RESULTS: CPC is an outstanding skeletal defect restorative material. Considering physico-chemical properties, drug release dynamics and histocompatibility, CPC is good delayed release carrier of drugs. However, its clinical application is limited only in bone defect repair of unloading sites due to its bad compressive strength and adhesivity. Therefore, studies on these aspects require exploration.CONCLUSION: CPC as a drug delivery system is a novel administration method. It can repair bone defect and release drug to achieve favorable treatment effects. CPC has been extensively used in osteomyelitis, bone tuberculosis, bone tumor, bone fracture, bone nonunion, and artificial joint replacement.