CAJ | 학술논문

基于Homin的基因共表达网络的比较分析,发现人类基因共表达网络和蛋白质相互作用数据之间存在一定的相关性.采用基因本体论对这两个网络重叠区域进行基因分类后发现,这些编码的蛋白质主要集中在对刺激物的应答途径之中.通过对该途径中的蛋白质相互作用网络作图,获得了两个独立的功能模块.通过对模块中的基因分类和关键基因分析得出两者分别对应于内外源刺激物的应答功能.本研究对于利用不断丰富的核酸公共数据信息挖掘蛋白质相互作用的研究具有积极的促进作用.
기우Homin적기인공표체망락적비교분석,발현인류기인공표체망락화단백질상호작용수거지간존재일정적상관성.채용기인본체론대저량개망락중첩구역진행기인분류후발현,저사편마적단백질주요집중재대자격물적응답도경지중.통과대해도경중적단백질상호작용망락작도,획득료량개독립적공능모괴.통과대모괴중적기인분류화관건기인분석득출량자분별대응우내외원자격물적응답공능.본연구대우이용불단봉부적핵산공공수거신식알굴단백질상호작용적연구구유적겁적촉진작용.
Based on comparative analysis of Homin's gene coexpression network,there was certain relativity between human gene coexpression network and protein-protein interaction data. The overlap regions between them were classified by gene ontology and indicated that most proteins encoded by genes fall into the response pathway on stimulus. Furthermore,a protein-protein interaction network was developed in this pathway and two independence modules were obtained.Through analyze the key genes in the modules,we conclude that the two modules are response to inner and outer stimulus. This study will accelerate protein-protein interaction research through mining public nucleic acid data enhanced unceasingly.