CAJ | 학술논문

目的:通过实验研究揭示海洛因成瘾与由之所致肾损害及横纹肌损害之间的关系.方法:应用免疫组织化学及透射电镜扫描的研究方法,对11例海洛因成瘾尸体肾脏及腓肠肌组织进行透射电镜观察.结果:肾组织免疫组织化学研究,11例中6例检出肌红蛋白成份;对上述尸体肾脏及腓肠肌进行透射电镜扫描观察,不同程度地显示了一定的形态学特征.结论:肾组织中肌红蛋白的检出,揭示了海洛因滥用及其所致肾损害和横纹肌损害之间的关系,指出海洛因所致横纹肌溶解症的存在及其与海洛因成瘾者临床肌痛之间的关系.强调在海洛因所致横纹肌溶解症死者的肾脏组织中,如若采用免疫组织化学的方法可检出肌红蛋白的成份.对海洛因所致其它脏器组织的形态学改变及其成因进行了讨论.
목적:통과실험연구게시해락인성은여유지소치신손해급횡문기손해지간적관계.방법:응용면역조직화학급투사전경소묘적연구방법,대11례해락인성은시체신장급비장기조직진행투사전경관찰.결과:신조직면역조직화학연구,11례중6례검출기홍단백성빈;대상술시체신장급비장기진행투사전경소묘관찰,불동정도지현시료일정적형태학특정.결론:신조직중기홍단백적검출,게시료해락인람용급기소치신손해화횡문기손해지간적관계,지출해락인소치횡문기용해증적존재급기여해락인성은자림상기통지간적관계.강조재해락인소치횡문기용해증사자적신장조직중,여약채용면역조직화학적방법가검출기홍단백적성빈.대해락인소치기타장기조직적형태학개변급기성인진행료토론.
The renal tissue in eleven heroin addicts was studied by immunohistochemical technique and the myoglobin was demonstrated in six of them. The kidney, soleus and myocardium were studied using transmission electron microscopical technique (TEM) as well. The presence of myoglobin in kidney and the related changes on striped muscle documented the relation between the renal damage and rhabdomyolysis in heroin addiction. The effects of heroin on other tissues were observed grossly and microscopically.