CAJ | 학술논문

目的：观察消瘤平移合剂与化疗结合应用对肿瘤术后患者抗转移、复发及抑瘤方面的作用。方法：96例常见肿瘤术后患者随机分为两组，观察组(58例)采用消瘤平移合剂加化疗，对照组(38例)单纯化疗，治疗2个疗程后，观察两组近期(1年)远处转移、原位复发的情况；复发转移者继续治疗2个月后，观察其病灶大小的变化，并观察治疗前后生活质量、体重、外周血细胞、免疫学、血液流变学指标变化。结果：观察组远处转移率、局部复发率分别为8.62%、15.52%，显著低于对照组的44.74%、60.53%(P＜0.01)。对于复发转移者其近期客观疗效，观察组有效率为46.24%，对照组有效率为24.00%，两组间差异有显著性(P＜0.05)。消瘤平移合剂能够提高患者生活质量，调节T细胞亚群的失衡，改变血液流变性，并降低化疗的毒副作用。结论：消瘤平移合剂配合化疗对常见肿瘤术后患者具有抑瘤、抗转移、抗复发作用。
목적：관찰소류평이합제여화료결합응용대종류술후환자항전이、복발급억류방면적작용。방법：96례상견종류술후환자수궤분위량조，관찰조(58례)채용소류평이합제가화료，대조조(38례)단순화료，치료2개료정후，관찰량조근기(1년)원처전이、원위복발적정황；복발전이자계속치료2개월후，관찰기병조대소적변화，병관찰치료전후생활질량、체중、외주혈세포、면역학、혈액류변학지표변화。결과：관찰조원처전이솔、국부복발솔분별위8.62%、15.52%，현저저우대조조적44.74%、60.53%(P＜0.01)。대우복발전이자기근기객관료효，관찰조유효솔위46.24%，대조조유효솔위24.00%，량조간차이유현저성(P＜0.05)。소류평이합제능구제고환자생활질량，조절T세포아군적실형，개변혈액류변성，병강저화료적독부작용。결론：소류평이합제배합화료대상견종류술후환자구유억류、항전이、항복발작용。
Objective: To observe the effect of combined use of chemotherapy(CT) and Xiaoliu Pingyi Mixture (XLPYM) in anti-metastasis, anti-relapse and tumor inhibition in patients after surgical operation. Methods: Ninety-six patients of common tumor after operation were divided into 2 groups, the 58 patients in the observed group treated with CT plus XLPYM and the 38 patients in the control group treated with CT alone. After 2 courses of treatment, the status of 1 year remote metastasis and in local relapse of tumor were observed. For patients of relapse or metastasis, another 2 courses of treatment was given, then the changes of tumor size, quality of life, body weight, peripheral blood cells, immunity and hemorrheology were estimated and compared between the two groups. Results: The remote metastatic rate and local relapse rate in the observed group were lower than those in the control group significantly (8.62% vs 44.74% and 15.52% vs 60.53%, P＜0.01). For patients of metastasis or relapse, the effective rate in the observed group was 46.24% and that in the control group was 24.00%, showing significant difference between the two groups (P＜0.05). Clinical observation also displayed that XLPYM could elevate the quality of life, regulate the disordered T-lymphocyte subsets, improve the hemorrheologic character and reduce the toxic-adverse reaction of CT in patients. Conclusion: XLPYM in combining with CT has effects of tumor inhibition, anti-metastasis and anti-relapse in treating patients of common tumor in post-operational period.