CAJ | 학술논문

目的研究内吗啡肽(EMs)及其类似物对心血管系统的影响，初步探讨其作用机理。方法测定EMs及其类似物对大鼠平均动脉压和后肢血管阻力、蟾蜍肠系膜微动脉内径、兔离体胸主动脉条张力的影响。结果 EMs及其类似物剂量依赖(10-9-10-6 mol*L-1，iv)且Nx敏感地降低麻醉大鼠平均动脉压、后肢血管灌流压和扩张蟾蜍肠系膜微动脉。EMs对去内皮兔离体胸主动脉条张力无影响；但剂量依赖地显著降低完整内皮胸主动脉条张力并被Nx和L-NNA阻断。结论 EMs及其类似物通过降低外周阻力而显著降低动脉血压，其作用与血管内皮细胞释放NO有关。
목적연구내마배태(EMs)급기유사물대심혈관계통적영향，초보탐토기작용궤리。방법측정EMs급기유사물대대서평균동맥압화후지혈관조력、섬서장계막미동맥내경、토리체흉주동맥조장력적영향。결과 EMs급기유사물제량의뢰(10-9-10-6 mol*L-1，iv)차Nx민감지강저마취대서평균동맥압、후지혈관관류압화확장섬서장계막미동맥。EMs대거내피토리체흉주동맥조장력무영향；단제량의뢰지현저강저완정내피흉주동맥조장력병피Nx화L-NNA조단。결론 EMs급기유사물통과강저외주조력이현저강저동맥혈압，기작용여혈관내피세포석방NO유관。
AIM　To analyze the effects of endomorphins (EMs) and their analogs (［D-Pro2］EM-1, ［D-Ala2］EM-1, ［D-Pro2］EM-2 and ［D-Ala2］EM-2) on the cardiovascular system of anesthetized rats and to study its mechanism. METHODS　Responses to EMs and their analogs were investigated in the systemic vascular bed of rats and the mesenteric microarteria of Bufo gargarizans. Responses to EMs were investigated on the hindquarters of the rat vascular bed under constant-flow conditions and on the isolated rabbit thoracic aorta strips. RESULTS　The EMs and their analogs showed dose-related (10-9-10-6 mol*L-1, iv) and naloxone-sensitive (2 mg*kg-1, iv) hypotension in mean arterial pressure of rats with similar duration and vasodilatation in mesenteric microarteria of Bufo gargarizans. The sequence of potencies was EMs > ［D-Pro2］EM-2 > ［D-Ala2］EM-2 > ［D-Ala2］EM-1 > ［D-Pro2］EM-1. EMs were shown not to relax the isolated rabbit thoracic aorta strips without endothelium. EMs, however, relaxed them with endothelium significantly. This action was blocked by Nx (10-5 mol*L-1) and L-NNA (10-4 mol*L-1). CONCLUSION　The significant hypotensive activity of EMs and their analogs is mainly associated with their vasodilatation, which is related to the release of NO from vascular endothelium, and their potency is not completely related to their affinity for μ-opiate receptor.