物理化学学报
物理化學學報
물이화학학보
ACTA PHYSICO-CHIMICA SINICA
2001年
5期
389-392
,共4页
倪立生%毛凤楼%韩玉真%来鲁华
倪立生%毛鳳樓%韓玉真%來魯華
예립생%모봉루%한옥진%래로화
蛋白质结构预测%折叠模式识别%低同源性%收敛进化%基因组
蛋白質結構預測%摺疊模式識彆%低同源性%收斂進化%基因組
단백질결구예측%절첩모식식별%저동원성%수렴진화%기인조
The development of human genome project calls for more rapid and accurate protein structure prediction method to assign the structure and function of gene products. Threading has been proved to be successful in protein fold assignment,although difficulties remain for low homologous sequences. We have developed a method for solving the sequence rearrangement problem in threading. By reshuffling secondary elements,protein structures with the same spatial arrangement of secondary structures but different connections can be predicted. This method has been proved to be useful in fold recognition for proteins of different evolutionary origin and converge to the same fold.
