CAJ | 학술논문

测定了52例初发未治急性髓性白血病（AML）患者血清胆固醇浓度及其外周血白血病细胞对125I-低密度脂蛋白（125I-LDL）的降解率，结果显示两者呈负相关，白细胞数及125I-LDL降解率较高者血清胆固醇浓度较低，化疗后，随着外周血白血病细胞消失，血清胆固醇及LDL胆固醇水平升高。据此推测AML患者的低胆固醇血症可能归因于白血病细胞的LDL受体活性增高，白血病细胞对LDL的高摄取及降解为利用LDL作为化疗药物的载体靶向治疗白血病提供了新思路。
측정료52례초발미치급성수성백혈병（AML）환자혈청담고순농도급기외주혈백혈병세포대125I-저밀도지단백（125I-LDL）적강해솔，결과현시량자정부상관，백세포수급125I-LDL강해솔교고자혈청담고순농도교저，화료후，수착외주혈백혈병세포소실，혈청담고순급LDL담고순수평승고。거차추측AML환자적저담고순혈증가능귀인우백혈병세포적LDL수체활성증고，백혈병세포대LDL적고섭취급강해위이용LDL작위화료약물적재체파향치료백혈병제공료신사로。
The serum cholesterol concentration and the rates of degradationof 125 I-low density lipoprotein（125I-LDL）by isolated leukemic cells of 52 patients with acute myeloblastic leukemia at diagnosis were assayed.The results showed that the lowest serum cholesterol concentrations were found in the patients with very high rates of cellular degradation of 125 I-LDL.After chemotherapy，both LDL cholesterol and total serum cholesterol levels rosed concomitantly with the fall in white blood cell counts.This suggests that a high receptor-mediated uptake and degradation of LDL by the leukemic cells may be the cause of hypocholesterolaemia in acute myeloblastic leukemia.LDL-receptor activity in leukemic cells may provide a basis for therapeutic approaches.