CAJ | 학술논문

目的：探讨多中心血管滤泡性淋巴组织增生（MCD）的临床病理特征。方法：8例血管滤泡性淋巴组织增生（CD）经组织病理证实，并按Frizzera的标准病理分型为PC型、Mix型和HV型。MCD的诊断除了组织学为CD外，必须有至少一组淋巴结病变，并且行淋巴结广泛切除术。结果：淋巴结组织病理PC型6例(75%)，Mix型1例，HV型1例。临床有系统性症状6例(75%);肝脾肿大3例(37.5%);术后6—66月复发5例(62.5%)，其中1例(12.5%)发展为恶性淋巴瘤。结论：MCD倾向于复发进展潜在恶性的临床过程，其发病机制尚待进一步探讨；密切随访观察可早期发现微小病灶和继发的恶性病变；MCD者应选择多种模式的治疗方法。
목적：탐토다중심혈관려포성림파조직증생（MCD）적림상병리특정。방법：8례혈관려포성림파조직증생（CD）경조직병리증실，병안Frizzera적표준병리분형위PC형、Mix형화HV형。MCD적진단제료조직학위CD외，필수유지소일조림파결병변，병차행림파결엄범절제술。결과：림파결조직병리PC형6례(75%)，Mix형1례，HV형1례。림상유계통성증상6례(75%);간비종대3례(37.5%);술후6—66월복발5례(62.5%)，기중1례(12.5%)발전위악성림파류。결론：MCD경향우복발진전잠재악성적림상과정，기발병궤제상대진일보탐토；밀절수방관찰가조기발현미소병조화계발적악성병변；MCD자응선택다충모식적치료방법。
Purpose：To study the clinical and pathological characteristics of multicentric angiofollicular lymph node hyperplasia (MCD).Methods：Eight patients with histologic diagnosis of angiofollicular lymph node hyperplasia (CD) were identified in the pathologic data base.The lymph node lesions were categorized as PC,Mix and HV types according to the criteria described by Frizzera. Patient with MCD had to have histology of CD within at least one regional group of lymph nodes and all underwent extensive lymphadenectomy.Results：The histologic features of 8 patients were six with PC,one with Mix and one with HV.Five patients presented with systemic symptoms. Three patients had splenomegaly and hapatomegaly. Five patients had local recurrence.Conclusions：MCD tends to recur and has a progressive clinical course with potential for malignancy ,and further study is needed to clarify the pathogenesis. Close follow-up and periodic surveillance are necessary to detect minimal disease and secondary malignant lesions. The patients with MCD should be candidates for multimodality therapy.