CAJ | 학술논문

目的：建立心功能不全的动物模型，探讨养心康在血流动力学方面的作用及其作用机理。方法：通过增加腹主动脉压力负荷而建立心功能不全的兔模型，以高、低两种不同剂量的养心康治疗 20 d，以心宝作为药物对照，并设立模型对照和空白对照，观察各组模型血流动力学指标及血液中一氧化氮水平在治疗前后的变化。结果：大剂量养心康能明显降低心衰模型的心率、收缩压、左室舒张末压(LVEDP)，心室等容收缩期中室内压上升的最大速率（+dp/dtmax）及心室等容舒张期中室内压下降的最大速率(-dp/dtmax)，且呈剂量依赖性，与心宝对照组相比具有显著性差异。结论：养心康能剂量依赖性地改善心衰模型的血流动力学指标，延缓心衰的进程，其作用可能与一氧化氮的降低有关。
목적：건립심공능불전적동물모형，탐토양심강재혈류동역학 방면적작용급기작용궤리。방법：통과증가복주동맥압력부하이건립 심공능불전적토모형，이고、저량충불동제량적양심강치료 20 d，이심보작위약물대조， 병설립모형대조화공백대조，관찰각조모형혈류동역학지표급혈액중일양화담수평재치료전 후적변화。결과：대제량양심강능명현강저심쇠모형적심솔、수축압 、좌실서장말압(LVEDP)，심실등용수축기중실내압상승적최대속솔（+dp/dtmax）급심실등 용서장기중실내압하강적최대속솔(-dp/dtmax)，차정제량의뢰성，여심보대조조상비구유현저성차이。결론：양 심강능제량의뢰성지개선심쇠모형적혈류동역학지표，연완심쇠적진정，기작용가능여일양화담적강저유관。
Objective:To observe the effects of Y angxink ang on hemodynamic indexes of heart failure (HF) in rabbits and to stud y its possible mechanism.Methods:The HF rabbit model was estab lished by increasing the pressure load on abdominal aorta.Rabbits receiving high and low dosages of Yangxinkang served as the treatment grou ps,others receiving Xinbao as the positive control group.Model control group and blank control group were also set up.Indexes such as heart ra te(HR),systolic blood pressure(SBP),left ventricular end-diastolic pressure(LVED P)and ±dp/dtmaxwere observed.The level of nitric oxide(NO)was also measur ed.Results:High dosage of Yangxinkang could decrease HR,SBP and LVEDP,and improve±dp/dtmax at the same time,the effec ts being dose-dependent.The differences were significant as compared with Xinbao group(P＜0.01 or P＜0.05).Conclusion:Yangxinkang can im prove the cardiac function of the HF model, delay the process of HF. Its mechani sm is probably related to the decrease of serum NO level.