中山大学学报(自然科学版)
中山大學學報(自然科學版)
중산대학학보(자연과학판)
ACTA SCIENTIARUM NATURALIUM UNIVERSITATIS SUNYATSENI
2001年
2期
65-67
,共3页
陈琪%朱海亮%戚穗坚%彭文烈%徐安龙
陳琪%硃海亮%慼穗堅%彭文烈%徐安龍
진기%주해량%척수견%팽문렬%서안룡
银(Ⅰ)配合物%六氮杂环希夫碱%抗肿瘤活性%细胞毒性
銀(Ⅰ)配閤物%六氮雜環希伕堿%抗腫瘤活性%細胞毒性
은(Ⅰ)배합물%륙담잡배희부감%항종류활성%세포독성
研究9个Ag(Ⅰ)与双螯合六氮杂环希夫碱（L）配合物的体外抗肿瘤活性.结果显示9个配合物对癌细胞生长都有较强的抑制作用.其生物活性的大小可能与配合物单元中Ag(Ⅰ)原子的多少及其空间位阻有关.
研究9箇Ag(Ⅰ)與雙螯閤六氮雜環希伕堿（L）配閤物的體外抗腫瘤活性.結果顯示9箇配閤物對癌細胞生長都有較彊的抑製作用.其生物活性的大小可能與配閤物單元中Ag(Ⅰ)原子的多少及其空間位阻有關.
연구9개Ag(Ⅰ)여쌍오합륙담잡배희부감（L）배합물적체외항종류활성.결과현시9개배합물대암세포생장도유교강적억제작용.기생물활성적대소가능여배합물단원중Ag(Ⅰ)원자적다소급기공간위조유관.
Nine silver(Ⅰ) complexes (1～9) of macrocyclic Schiff base (L) with different anions have been prepared and structurally characterized, where L is a hexaaza-macrocyclic Schiff base derived from the ［2=2］condensation of terephthalaldehyde and 3-azapentane-1,5-diamine.The results of activity assay indicated that 1～9 strongly inhibit the growth of several human solid carcinoma cell lines. Their anti-tumor activities are possibly related to the amount and the emplacement of Ag(Ⅰ) in the complexes.
