CAJ | 학술논문

目的：观察大剂量胸腺肽(thymopeptide,TP)对恶性肿瘤放疗病人T细胞亚群的影响。方法：51例恶性肿瘤放疗病人分为100 mg和200 mg胸腺肽用药组。病人分别每日静点胸腺肽 100 mg和200 mg，连续10日用药。用流式细胞仪测其用药前后外周血T细胞CD4、CD8、C D25 和CD56阳性百分率。结果：100 mg用药组病人用药后外周血T细胞CD4和CD25阳性百分率明显高于用药前水平(P<0.05)，而200 mg用药组病人用药后外周血T细胞CD4、CD8 、CD25和CD56阳性百分率均明显增高(P<0.05或P<0.01)。结论：大剂量胸腺肽可在短时间内提高恶性肿瘤放疗病人细胞免疫功能，而且每日200 mg用药量效果更佳。
목적：관찰대제량흉선태(thymopeptide,TP)대악성종류방료병인T세포아군적영향。방법：51례악성종류방료병인분위100 mg화200 mg흉선태용약조。병인분별매일정점 흉선태 100 mg화200 mg，련속10일용약。용류식세포의측기용약전후외주혈T세포CD4、CD8、C D25 화CD56양성백분솔。결과：100 mg용약조병인용약후외주혈T세포CD4화CD25양성백분솔 명현고우용약전수평(P<0.05)，이200 mg용약조병인용약후외주혈T세포CD4、CD8 、CD25화CD56양성백분솔균명현증고(P<0.05혹P<0.01)。 결론：대제량흉선태가재단시간내제고악성종류방료병인세포면역공능，이차매일200 mg용 약량효과경가。
Objective:To study effects of large dose thymopeptides on T cell subpopulations of patients with malignant tumor under radiotherapy.Methods:Fifty one patients with malignant tumor under radiotherapy were divided into 2 groups with 100 mg and 200 mg thymopeptides respectively.The patients we re given thymopeptides,100 mg/d or 200 mg/d,iv, for 10 days.The positive percent ages of CD4,CD8,CD25 and CD56 in T cells of peripheral blood before and after thymopeptide treatment were determined by flow cytometry.Results:The positive percentages of CD4 and CD25 in T cells of peripheral bl ood after 100 mg/d thymopeptide treatment were significantly higher than those befor e thymopeptide treatment (P<0.05),while those of CD4，CD8，CD25 and CD56 in T cells of peripheral blood after 200 mg/d thymopeptide treatment all increased significantly (P<0.05 or P<0.01). Conclusion:These results suggest that large dose of thymopeptides can increase i mmune function of patients with malignant tumor under radiotherapy,and the curat ive effect of 200 mg/d thymopeptides is better.