CAJ | 학술논문

目的：探讨常用中药的组合——“对药”和非“对药”间，在化学成分、分子结构、构型、构象方面的相似性差异。方法：(1)按中药多分子体系的脂溶性差异，分为石油醚、氯仿、乙酸乙脂、乙醇和水的溶出性成分集合，然后进行“对药”与非“对药”的对比分析；(2)用紫外-可见光光度计测定吸收光谱曲线。结果：分析225份样品，约1300个数据，9对“对药”中有6对分别显示：紫外-可见光吸收光谱峰的分布区域重叠较大；相同波峰数和相同波谷数较多；组合后吸收光谱曲线下面积增加趋势较大。结论：提示化学成分相近，分子结构或构型、构象相似是中药(植物药)组方配伍的原则之一。
목적：탐토상용중약적조합——“대약”화비“대약”간，재화학성분、분자결구、구형、구상방면적상사성차이。방법：(1)안중약다분자체계적지용성차이，분위석유미、록방、을산을지、을순화수적용출성성분집합，연후진행“대약”여비“대약”적대비분석；(2)용자외-가견광광도계측정흡수광보곡선。결과：분석225빈양품，약1300개수거，9대“대약”중유6대분별현시：자외-가견광흡수광보봉적분포구역중첩교대；상동파봉수화상동파곡수교다；조합후흡수광보곡선하면적증가추세교대。결론：제시화학성분상근，분자결구혹구형、구상상사시중약(식물약)조방배오적원칙지일。
Objective:To study the difference between the pairing herbs i.e. commonly used combinations of two Chinese medicinal herbs,and nonpairing herbs in the similarity of chemical components and their molecular structure (configuration and conformation).Methhods:1:The chemical components of Chinese herbal medicines(singles or combinations) extracted with petroleum ether,chloroform, ethyl acetate,ethenol and water respectively were analyzed and compared.2.The specimens were analyzed with ultraviolet-visible absorption spectrophotometry.Results:1300 data were obtained from 225 specimens analysed.6 out of 9 pairs of compactible herbs showed wider range of overlaped ultraviolet-visible absorption peaks and relatively more identical peaks and trough and the areas under the curves showed a tendency to increase.Conclusion:The similarity of chemical components,and their molecular structure (configuration and conformation) was one of the mechanisms of the compactibility and combinability of Chinese medicinal herbs.