苏州医学院学报
囌州醫學院學報
소주의학원학보
JACTA ACADEMIAE MEDICINAE SUZHOU
2001年
1期
53-54,61
,共3页
庄建平%周先举%卢建林%樊峰%钱润卿
莊建平%週先舉%盧建林%樊峰%錢潤卿
장건평%주선거%로건림%번봉%전윤경
肾癌%多药耐药基因%逆转录-聚合酶链反应
腎癌%多藥耐藥基因%逆轉錄-聚閤酶鏈反應
신암%다약내약기인%역전록-취합매련반응
目的 探讨肾癌患者多药耐药与组织学分级和临床病理学分期之间的关系。方法 采用逆转录-聚合酶链反应(RT-PCR)方法定量检测36例肾癌和15例正常肾组织的mdr-1表达水平。结果 肾癌的mdr-1表达水平与肾癌的组织分级有相关性，而与临床病理分期无关。结论 临床检测肾癌患者mdr-1基因的表达，可以预测患者对化疗的敏感性，为临床选 用化疗药物提供依据。
目的 探討腎癌患者多藥耐藥與組織學分級和臨床病理學分期之間的關繫。方法 採用逆轉錄-聚閤酶鏈反應(RT-PCR)方法定量檢測36例腎癌和15例正常腎組織的mdr-1錶達水平。結果 腎癌的mdr-1錶達水平與腎癌的組織分級有相關性，而與臨床病理分期無關。結論 臨床檢測腎癌患者mdr-1基因的錶達，可以預測患者對化療的敏感性，為臨床選 用化療藥物提供依據。
목적 탐토신암환자다약내약여조직학분급화림상병이학분기지간적관계。방법 채용역전록-취합매련반응(RT-PCR)방법정량검측36례신암화15례정상신조직적mdr-1표체수평。결과 신암적mdr-1표체수평여신암적조직분급유상관성，이여림상병리분기무관。결론 림상검측신암환자mdr-1기인적표체，가이예측환자대화료적민감성，위림상선 용화료약물제공의거。
Purpose To investigate the relationship between multidrug resistance of kidney carcinoma,and histological differentiation and clinicopathological staging.Methods The expression of multidrug resistance gene mdr-1 was detected in 36 kidney carcinoma samples and 15 normal kidneys with RT-PCR(reverse transcription polymerase chain reaction).Results The level of mdr-1 gene expression in kidney carcinoma appears to be correlative with the degree of histological differentiation,but not with the clinicopathological staging.The difference of the level of mdr-1 gene expression between kidney carcinoma and normal kidney tissue is very distint.Conclusion Detection of the mdr-1 gene expression in kidney carcinoma may predict the patients' sensitivity to chemotherapy and provide a basis for clinical selection of chemotheraputic drugs.
