解放军药学学报
解放軍藥學學報
해방군약학학보
PHARMACEUTICAL JOURNAL OF CHINESE PEOPLE'S LIBERATION ARMY
2001年
1期
51-53
,共3页
张金国%高东升%董志巨%沈彩云%刘雪玲%刘立新%董殿阶%毕宁康%李成乔%LI Cheng-Qiao%董坤
張金國%高東升%董誌巨%瀋綵雲%劉雪玲%劉立新%董殿階%畢寧康%李成喬%LI Cheng-Qiao%董坤
장금국%고동승%동지거%침채운%류설령%류립신%동전계%필저강%리성교%LI Cheng-Qiao%동곤
不稳定型心绞痛%心肌梗死%硝苯地平控释片
不穩定型心絞痛%心肌梗死%硝苯地平控釋片
불은정형심교통%심기경사%초분지평공석편
目的 探讨硝苯地平控释片对不稳定型心绞痛的治疗作用。方法 对134例不稳定型心绞痛患者随机单盲分为常规治疗(对照组)及常规+硝苯地平控释片治疗(治疗组)组。分别于治疗后1、2周根据心绞痛分级变化及心电图改善情况评价治疗效果。结果 治疗组1周显效率为41.5%,总有效率为70.8%，2周总有效率93.8%，高于对照组(P<0.05)；2周显效率81.5%，明显高于对照组(P<0.01)。住院观察6周，心肌梗死发生率1.5%,对照组7.3%(P>0.05)；死亡率治疗组3.1%，对照组5.8%(P>0.05)；治疗组未见明显不良反应。结论 硝苯地平控释片与常规药物并用治疗不稳定型心绞痛，能迅速控制症状，对降低心肌梗死发生及死亡率可能有益。
目的 探討硝苯地平控釋片對不穩定型心絞痛的治療作用。方法 對134例不穩定型心絞痛患者隨機單盲分為常規治療(對照組)及常規+硝苯地平控釋片治療(治療組)組。分彆于治療後1、2週根據心絞痛分級變化及心電圖改善情況評價治療效果。結果 治療組1週顯效率為41.5%,總有效率為70.8%，2週總有效率93.8%，高于對照組(P<0.05)；2週顯效率81.5%，明顯高于對照組(P<0.01)。住院觀察6週，心肌梗死髮生率1.5%,對照組7.3%(P>0.05)；死亡率治療組3.1%，對照組5.8%(P>0.05)；治療組未見明顯不良反應。結論 硝苯地平控釋片與常規藥物併用治療不穩定型心絞痛，能迅速控製癥狀，對降低心肌梗死髮生及死亡率可能有益。
목적 탐토초분지평공석편대불은정형심교통적치료작용。방법 대134례불은정형심교통환자수궤단맹분위상규치료(대조조)급상규+초분지평공석편치료(치료조)조。분별우치료후1、2주근거심교통분급변화급심전도개선정황평개치료효과。결과 치료조1주현효솔위41.5%,총유효솔위70.8%，2주총유효솔93.8%，고우대조조(P<0.05)；2주현효솔81.5%，명현고우대조조(P<0.01)。주원관찰6주，심기경사발생솔1.5%,대조조7.3%(P>0.05)；사망솔치료조3.1%，대조조5.8%(P>0.05)；치료조미견명현불량반응。결론 초분지평공석편여상규약물병용치료불은정형심교통，능신속공제증상，대강저심기경사발생급사망솔가능유익。
Aim To assess the efficacy of nifedipine gastrointestinal therapeutic system (nifedipine GITS) combination with conventional treatment in patients with unstable angina pectoris.Methods 134 consecutive patients with unstable angina admitted to our hospital were randomly divided into 2 groups i.e.control group (conventional treatment n=69) and treatment group (nifedipine GITS 30mg qd plus conventional medicine,n=65).According to the change of angina pectoris grade and the improvement of electrocardiogram,the efficacy was assessed a week and two weeks after treatment.Results The results showed that prominent effect rate and overall effect rate were 41.5% and 70.8% in the first week,81.5% and 93.8% in the second week for the treatment group respectively(P<0.05 and 0.01,vs control).The incidence of acute myocardial infarction was 1.5% in the treastment group and 7.3% in the control group during 6 weeks hospitalization (P>0.05),as well the mortality rate were 3.1% and 5.8%,respectively(P>0.05).There was no obvious adverse reaction reported during nifedipine GITS administration.Conclusion Nifedipine GITS in combination with conventional medicine could control the symptoms of unstable angina quickly and may be useful to the reduction of attack and mortality rate of myocardium.
