CAJ | 학술논문

本文回顾了T、B淋巴细胞功能与牛白血病发生发展的相关性。阐明了感染BLV牛B细胞淋巴瘤细胞除了来源于B1a(CD5+CD11b+)细胞，也可来源于B1b(CD5－ CD11b+)及常规B2(CD5 －CD11b－)细胞。探讨了T细胞功能对牛白血病的发生发展的影响，指出IL-1 2表达下降和IL -10表达增加可能导致了B细胞淋巴肉瘤的形成，Ⅰ型和Ⅱ型细胞因子的不平衡引起了BLV的发展。同时讨论了B-T细胞的相互作用在BLV感染时疾病阶段性发展过程中的作用。
본문회고료T、B림파세포공능여우백혈병발생발전적상관성。천명료감염BLV우B세포림파류세포제료래원우B1a(CD5+CD11b+)세포，야가래원우B1b(CD5－ CD11b+)급상규B2(CD5 －CD11b－)세포。탐토료T세포공능대우백혈병적발생발전적영향，지출IL-1 2표체하강화IL -10표체증가가능도치료B세포림파육류적형성，Ⅰ형화Ⅱ형세포인자적불평형인기료BLV적발전。동시토론료B-T세포적상호작용재BLV감염시질병계단성발전과정중적작용。
This review focuses on the relationship between the function of T、B lymp hocytes and the pathogenesis of Enzootic Bovine Leukosis. In BLV infection anima l, the phenotypes of B-cells lymphoma can be derived from B1a(CD5+CD11 b+), B1b(C D5－CD11b+) and conventional B2(CD5－CD11b－)cells. Co mbined with previous findi ngs the data suggests that the decrease of IL-12 and the increase of IL-10 res ult in the formation of B-cell lymphosarcoma, and the imbalance of phenotype Ⅰ　and Ⅱ cytokines causes the progression of Bovine Leukemia. M eanwhile, the interaction of B and T cells could contribute to the polyclonal ac tivation and proliferation of B lymphocytes in BLV infectea animals.